The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology

Danielle B. P. Eekers*, Lieke in 't Ven, Erik Roelofs, Alida Postma, Claire Alapetite, Neil G. Burnet, Valentin Calugaru, Inge Compter, Ida E. M. Coremans, Morton Hoyer, Maarten Lambrecht, Petra Witt Nystrom, Alejandra Mendez Romero, Frank Paulsen, Ana Perpar, Dirk de Ruysscher, Laurette Renard, Beate Timmermann, Pavel Vitek, Damien C. WeberHiske L. van der Weide, Gillian A. Whitfield, Ruud Wiggenraad, Esther G. C. Troost, Taskforce European Particle

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Web of Science)

Abstract

Purpose: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (Cr) and magnetic resonance (MR) imaging. Methods: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published. The draft atlas was delineated by a senior radiation oncologist, 2 residents in radiation oncology, and a senior neuro-radiologist incorporating relevant available literature. The proposed atlas was then critically reviewed and discussed by European radiation oncologists until consensus was reached. Results: The online atlas includes one CT-scan at two different window settings and one MR scan (3T) showing the OARs in axial, coronal and sagittal view. This manuscript presents the three-dimensional descriptions of the fifteen consensus OARs for neuro-oncology. Among these is a new OAR relevant for neuro-cognition, the posterior cerebellum (illustrated on 7T MR images). Conclusion: In order to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology and thus derive consistent dosimetric data, we propose this atlas to be used in photon and particle therapy. The atlas is available online at w.cancerdata.c and will be updated whenever required. (C) 2017 The Authors. Published by Elsevier B.V.
Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalRadiotherapy and Oncology
Volume128
Issue number1
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Atlas for neuro-oncology
  • Organs at risk
  • Particle therapy
  • European Particle Therapy Network
  • INTENSITY-MODULATED RADIOTHERAPY
  • RADIATION ONCOLOGISTS GUIDE
  • WHOLE-BRAIN RADIOTHERAPY
  • NASOPHARYNGEAL CARCINOMA
  • NECK-CANCER
  • NEUROCOGNITIVE FUNCTION
  • CRANIAL IRRADIATION
  • PROTON THERAPY
  • HEARING-LOSS
  • HEAD

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