The entanglement of plasma Cathepsin D and metabolic disturbances: relevant insights in the metabolic syndrome

Lingling Ding

Research output: ThesisDoctoral ThesisInternal

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Metabolic syndrome has become an escalating public health threat, which is strongly linked to type 2 diabetes and fatty liver disease. For the treatment of type 2 diabetes, organ-specific interventions are beneficial to achieve higher intervention efficiency via determining organ-specific insulin resistance. This research demonstrated plasma Cathepsin D (a lysosomal enzyme) might be a useful marker to determine hepatic insulin sensitivity in pre(diabetic) individuals, thereby providing support for clinicians to apply the organ-specific therapy for diabetic patients. Furthermore, this study also indicated that plasma Cathespin D is increased in type 2 diabetic patients, suggesting plasma Cathepsin D is likely involved in the pathogenesis of type 2 diabetes and can be a potential target for treatment of type 2 diabetes. Considering no effective pharmaceutic therapy for fatty liver disease, this thesis proposes that plasma Cathepsin D might be a promising target for the prevention and treatment of fatty liver disease as insulin resistance might contribute to fatty liver disease progression via elevation of plasma Cathepsin D.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Shiri - Sverdlov, Ronit, Supervisor
  • Houben, Tom, Co-Supervisor
Award date18 May 2021
Place of PublicationMaastricht
Print ISBNs9789464191998
Publication statusPublished - 2021


  • plasma Cathepsin D
  • metabolic syndrome
  • type 2 diabetes
  • fatty liver disease
  • insulin resistance
  • myosteatosis

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