The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target

Dipanjan Chanda; Dietbert Neumann; Jan F. C. Glatz

doi:10.1016/j.plefa.2018.11.016

The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target

Dipanjan Chanda, Dietbert Neumann, Jan F. C. Glatz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	140
DOIs	https://doi.org/10.1016/j.plefa.2018.11.016
Publication status	Published - Jan 2019

Keywords

2-arachidonoylglyerol
Anandamide
Insulin resistance
Ccardiovascular disease
CB2 CANNABINOID RECEPTORS
PHARMACOLOGICAL STRATEGIES
SPECIES-DIFFERENCES
RISK-FACTORS
RIMONABANT
PAIN
IDENTIFICATION
HYPOTHALAMUS
MODULATION
OVERWEIGHT

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10.1016/j.plefa.2018.11.016

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Cite this

@article{6fa28b29e9eb42ec94d8634b0012f59a,

title = "The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target",

abstract = "The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.",

keywords = "2-arachidonoylglyerol, Anandamide, Insulin resistance, Ccardiovascular disease, CB2 CANNABINOID RECEPTORS, PHARMACOLOGICAL STRATEGIES, SPECIES-DIFFERENCES, RISK-FACTORS, RIMONABANT, PAIN, IDENTIFICATION, HYPOTHALAMUS, MODULATION, OVERWEIGHT",

author = "Dipanjan Chanda and Dietbert Neumann and Glatz, {Jan F. C.}",

note = "Funding Information: This study was supported by a Marie Curie Individual Incoming Fellowship to DC ( PIIF-GA-2012-332230 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.plefa.2018.11.016",

language = "English",

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AU - Neumann, Dietbert

AU - Glatz, Jan F. C.

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