The emerging role of GATA transcription factors in development and disease

Marjolein Lentjes - Beer; Hanneke E. C. Niessen; Yoshimitsu Akiyama; Adriaan P. De Bruine; Veerle Melotte; Manon Van Engeland

doi:10.1017/erm.2016.2

The emerging role of GATA transcription factors in development and disease

Marjolein Lentjes - Beer
, Hanneke E. C. Niessen
, Yoshimitsu Akiyama
, Adriaan P. De Bruine
, Veerle Melotte
, Manon Van Engeland^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm-and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

Original language	English
Article number	e3
Journal	Expert Reviews in Molecular Medicine
Volume	18
DOIs	https://doi.org/10.1017/erm.2016.2
Publication status	Published - 8 Mar 2016

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10.1017/erm.2016.2Licence: CC BY

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abstract = "The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm-and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.",

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AU - Niessen, Hanneke E. C.

AU - Akiyama, Yoshimitsu

AU - De Bruine, Adriaan P.

AU - Melotte, Veerle

AU - Van Engeland, Manon

PY - 2016/3/8

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AB - The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm-and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

U2 - 10.1017/erm.2016.2

DO - 10.1017/erm.2016.2

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SN - 1462-3994

VL - 18

JO - Expert Reviews in Molecular Medicine

JF - Expert Reviews in Molecular Medicine

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The emerging role of GATA transcription factors in development and disease

Abstract

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