The emerging role of GATA transcription factors in development and disease

Marjolein Lentjes - Beer, Hanneke E. C. Niessen, Yoshimitsu Akiyama, Adriaan P. De Bruine, Veerle Melotte, Manon Van Engeland*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm-and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.
Original languageEnglish
Article numbere3
JournalExpert Reviews in Molecular Medicine
Publication statusPublished - 8 Mar 2016

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