The elusive particle hazard; inflammatory and oxidative stress response

D. van Berlo

    Research output: ThesisDoctoral ThesisExternal prepared

    Abstract

    Inhalation of fine dust particles creates a health danger. Two central, mutually connected phenomena that are assumed to play an important role here are (1) inflammation and (2) oxidative stress. This dissertation shows that the ‘dusty danger’ cannot be so easily defined: particles can cause inflammation related effects without causing oxidative stress or activating the main inflammation switch NF-κB. Indirect effects via stimulation of immune cells appear to be important. Moreover, this dissertation shows that fine dust particles can cause effects in the brains. This has consequences for the risk assessment of fine dust particles.

    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • van Schooten, Frederik, Supervisor
    • Schins, R.P., Advisor, External person
    Award date30 Jun 2010
    Publication statusPublished - 1 Jan 2010

    Keywords

    • dust particles
    • immune cells
    • risk assessment

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