Inhalation of fine dust particles creates a health danger. Two central, mutually connected phenomena that are assumed to play an important role here are (1) inflammation and (2) oxidative stress. This dissertation shows that the ‘dusty danger’ cannot be so easily defined: particles can cause inflammation related effects without causing oxidative stress or activating the main inflammation switch NF-κB. Indirect effects via stimulation of immune cells appear to be important. Moreover, this dissertation shows that fine dust particles can cause effects in the brains. This has consequences for the risk assessment of fine dust particles.
|Qualification||Doctor of Philosophy|
|Award date||30 Jun 2010|
|Publication status||Published - 1 Jan 2010|
- dust particles
- immune cells
- risk assessment