The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial

Philippe H. J. Hoogsteder; Daniel Kotz; Paul I. van Spiegel; Wolfgang Viechtbauer; Ruth Brauer; Paul D. Kessler; Matthew W. Kalnik; Raafat E. F. Fahim; Onno C. P. van Schayck

doi:10.1186/1471-2458-12-1052

The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial

Philippe H. J. Hoogsteder, Daniel Kotz, Paul I. van Spiegel, Wolfgang Viechtbauer, Ruth Brauer, Paul D. Kessler, Matthew W. Kalnik, Raafat E. F. Fahim, Onno C. P. van Schayck

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1052
Journal	BMC Public Health
Volume	12
DOIs	https://doi.org/10.1186/1471-2458-12-1052
Publication status	Published - 6 Dec 2012

Keywords

Nicotine vaccination
NicVAX
Varenicline
Combination therapy
Efficacy
Safety
Immunogenicity
Randomized controlled trial

Access to Document

10.1186/1471-2458-12-1052

Cite this

Hoogsteder, P. H. J., Kotz, D., van Spiegel, P. I., Viechtbauer, W., Brauer, R., Kessler, P. D., Kalnik, M. W., Fahim, R. E. F., & van Schayck, O. C. P. (2012). The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial. BMC Public Health, 12, 1052. https://doi.org/10.1186/1471-2458-12-1052

Hoogsteder, Philippe H. J. ; Kotz, Daniel ; van Spiegel, Paul I. ; Viechtbauer, Wolfgang ; Brauer, Ruth ; Kessler, Paul D. ; Kalnik, Matthew W. ; Fahim, Raafat E. F. ; van Schayck, Onno C. P. / The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial. In: BMC Public Health. 2012 ; Vol. 12. pp. 1052.

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keywords = "Nicotine vaccination, NicVAX, Varenicline, Combination therapy, Efficacy, Safety, Immunogenicity, Randomized controlled trial",

author = "Hoogsteder, {Philippe H. J.} and Daniel Kotz and {van Spiegel}, {Paul I.} and Wolfgang Viechtbauer and Ruth Brauer and Kessler, {Paul D.} and Kalnik, {Matthew W.} and Fahim, {Raafat E. F.} and {van Schayck}, {Onno C. P.}",

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Hoogsteder, PHJ, Kotz, D, van Spiegel, PI, Viechtbauer, W, Brauer, R, Kessler, PD, Kalnik, MW, Fahim, REF & van Schayck, OCP 2012, 'The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial', BMC Public Health, vol. 12, pp. 1052. https://doi.org/10.1186/1471-2458-12-1052

The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial. / Hoogsteder, Philippe H. J.; Kotz, Daniel; van Spiegel, Paul I.; Viechtbauer, Wolfgang; Brauer, Ruth; Kessler, Paul D.; Kalnik, Matthew W.; Fahim, Raafat E. F.; van Schayck, Onno C. P.

In: BMC Public Health, Vol. 12, 06.12.2012, p. 1052.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial

AU - Hoogsteder, Philippe H. J.

AU - Kotz, Daniel

AU - van Spiegel, Paul I.

AU - Viechtbauer, Wolfgang

AU - Brauer, Ruth

AU - Kessler, Paul D.

AU - Kalnik, Matthew W.

AU - Fahim, Raafat E. F.

AU - van Schayck, Onno C. P.

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KW - Varenicline

KW - Combination therapy

KW - Efficacy

KW - Safety

KW - Immunogenicity

KW - Randomized controlled trial

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JO - BMC Public Health

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SN - 1471-2458

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Hoogsteder PHJ, Kotz D, van Spiegel PI, Viechtbauer W, Brauer R, Kessler PD et al. The efficacy and safety of a nicotine conjugate vaccine (NicVAX (R)) or placebo co-administered with varenicline (Champix (R)) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial. BMC Public Health. 2012 Dec 6;12:1052. https://doi.org/10.1186/1471-2458-12-1052