The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis

Claudia Vingerhoets*, Geor Bakker, Jelske van Dijik, Oswald J. N. Bloemen, Ya Wang, Raymond C. K. Chan, Jan Booij, Therese A. M. J. van Amelsvoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Web of Science)

Abstract

The acetylcholine muscarinic M-1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M-1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M-1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M-1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M-1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled. All participants completed a comprehensive cognitive test battery twice: once after placebo and once after oral administration of 4 mg. biperiden (M-1 antagonist). The order of drug administration was counterbalanced. Biperiden significantly negatively influenced both verbal (p

Original languageEnglish
Pages (from-to)854-864
Number of pages11
JournalEuropean Neuropsychopharmacology
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 2017

Keywords

  • Psychosis
  • Muscarinic M-1 receptor
  • Acetylcholine
  • Cognition
  • Biperiden
  • HEALTHY-VOLUNTEERS
  • PREFRONTAL CORTEX
  • SCHIZOPHRENIA
  • BINDING
  • MEMORY
  • PSYCHOPATHOLOGY
  • RELIABILITY
  • SENSITIVITY
  • SCOPOLAMINE
  • IMPAIRMENT

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