The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss (R): an experimental study in goats

Robert E. C. M. Mooren*, A. C. A. Dankers, M. A. W. Merkx, Ewald M. Bronkhorst, J. A. Jansen, Paul J. W. Stoelinga

*Corresponding author for this work

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Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss) particles, in which 1 ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used. International Association of Oral and Maxillofacial Surgeons.
Original languageEnglish
Pages (from-to)371-378
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number4
Publication statusPublished - Apr 2010


  • platelet-rich plasma (PRP)
  • early and late bone healing
  • autogenous bone graft
  • bovine deproteinized bone mineral
  • goats

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