TY - JOUR
T1 - The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss (R): an experimental study in goats
AU - Mooren, Robert E. C. M.
AU - Dankers, A. C. A.
AU - Merkx, M. A. W.
AU - Bronkhorst, Ewald M.
AU - Jansen, J. A.
AU - Stoelinga, Paul J. W.
PY - 2010/4
Y1 - 2010/4
N2 - Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss) particles, in which 1 ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used. International Association of Oral and Maxillofacial Surgeons.
AB - Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss) particles, in which 1 ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used. International Association of Oral and Maxillofacial Surgeons.
KW - platelet-rich plasma (PRP)
KW - early and late bone healing
KW - autogenous bone graft
KW - bovine deproteinized bone mineral
KW - goats
U2 - 10.1016/j.ijom.2009.12.019
DO - 10.1016/j.ijom.2009.12.019
M3 - Article
C2 - 20129756
SN - 0901-5027
VL - 39
SP - 371
EP - 378
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 4
ER -