The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial

Yala Stevens*, Bjorn Winkens, Daisy Jonkers, Adrian Masclee

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Purpose Overweight and obesity are associated with many health problems, including cardiovascular disease (CVD). Evidence from previous studies has shown that extracts from olive leaves rich in olive phenolics are able to positively affect CVD risk factors, such as high blood pressure and dyslipidemia. The aim of this study was to investigate the effect of 8-week olive leaf extract (OLE) administration on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels. Methods In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 +/- 10 years and BMI 29.0 +/- 2.7 kg/m(2)) with total cholesterol levels of 5.0-8.0 mmol/L (5.9 +/- 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein (oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks. Results OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (allp > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (allp > 0.05). Conclusions Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels. Trial registered The trial has been registered at ClinicalTrials.gov (NCT02990637).

Original languageEnglish
Pages (from-to)2111-2120
Number of pages10
JournalEuropean Journal of Nutrition
Volume60
Issue number4
Early online date9 Oct 2020
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Blood lipid profiles
  • CONSUMPTION
  • Cardiovascular disease
  • DISEASE
  • FATTY-ACIDS
  • LIPOPROTEIN-CHOLESTEROL RATIO
  • MEDITERRANEAN DIET
  • METAANALYSIS
  • METABOLISM
  • MORTALITY
  • OLEA-EUROPAEA L.
  • OLEUROPEIN
  • Olive leaf extract
  • Overweight
  • OBESITY

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