Abstract

Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might have beneficial effects on early stages of wound healing. Trial Registration NTR3652, http://www.trialregister.nl.

Original languageEnglish
Pages (from-to)385-397
Number of pages13
JournalJournal of Behavioral Medicine
Volume41
Issue number3
DOIs
Publication statusPublished - Jun 2018

Keywords

  • Journal Article

Cite this

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title = "The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study",
abstract = "Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might have beneficial effects on early stages of wound healing. Trial Registration NTR3652, http://www.trialregister.nl.",
keywords = "Journal Article",
author = "Astrid Meesters and {Den Bosch-Meevissen}, {Yvo M. C. In} and Weijzen, {Chantal A. H.} and Buurman, {Wim A.} and Mario Losen and Jan Schepers and Thissen, {Monique R T M} and Alberts, {Hugo J E M} and Schalkwijk, {Casper G} and Peters, {Madelon L}",
year = "2018",
month = "6",
doi = "10.1007/s10865-017-9901-8",
language = "English",
volume = "41",
pages = "385--397",
journal = "Journal of Behavioral Medicine",
issn = "0160-7715",
publisher = "Springer",
number = "3",

}

The effect of Mindfulness-Based Stress Reduction on wound healing : a preliminary study. / Meesters, Astrid; Den Bosch-Meevissen, Yvo M. C. In; Weijzen, Chantal A. H.; Buurman, Wim A.; Losen, Mario; Schepers, Jan; Thissen, Monique R T M; Alberts, Hugo J E M; Schalkwijk, Casper G; Peters, Madelon L.

In: Journal of Behavioral Medicine, Vol. 41, No. 3, 06.2018, p. 385-397.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The effect of Mindfulness-Based Stress Reduction on wound healing

T2 - a preliminary study

AU - Meesters, Astrid

AU - Den Bosch-Meevissen, Yvo M. C. In

AU - Weijzen, Chantal A. H.

AU - Buurman, Wim A.

AU - Losen, Mario

AU - Schepers, Jan

AU - Thissen, Monique R T M

AU - Alberts, Hugo J E M

AU - Schalkwijk, Casper G

AU - Peters, Madelon L

PY - 2018/6

Y1 - 2018/6

N2 - Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might have beneficial effects on early stages of wound healing. Trial Registration NTR3652, http://www.trialregister.nl.

AB - Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might have beneficial effects on early stages of wound healing. Trial Registration NTR3652, http://www.trialregister.nl.

KW - Journal Article

U2 - 10.1007/s10865-017-9901-8

DO - 10.1007/s10865-017-9901-8

M3 - Article

C2 - 29159589

VL - 41

SP - 385

EP - 397

JO - Journal of Behavioral Medicine

JF - Journal of Behavioral Medicine

SN - 0160-7715

IS - 3

ER -