The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib

Karthick Vishwanathan; Paul A. Dickinson; Karen So; Karen Thomas; Yuh-Min Chen; Javier Carpeno; Anne-Marie C. Dingemans; Hye Ryun Kim; Joo-Hang Kim; Matthew G. Krebs; James Chih-Hsin Yang; Bui Bui; Doris Weilert; R. Donald Harvey

doi:10.1111/bcp.13534

The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib

Karthick Vishwanathan, Paul A. Dickinson, Karen So, Karen Thomas, Yuh-Min Chen, Javier Carpeno, Anne-Marie C. Dingemans, Hye Ryun Kim, Joo-Hang Kim, Matthew G. Krebs, James Chih-Hsin Yang, Bui Bui, Doris Weilert, R. Donald Harvey

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1156-1169
Number of pages	14
Journal	British Journal of Clinical Pharmacology
Volume	84
Issue number	6
DOIs	https://doi.org/10.1111/bcp.13534
Publication status	Published - 1 Jun 2018

Keywords

clinical pharmacology
drug metabolism
drug analysis
lung cancer
drug information
oncology
pharmacokinetics
biomarkers
drug interactions
CELL LUNG-CANCER
SYSTEMIC ANTIMYCOTICS KETOCONAZOLE
GROWTH-FACTOR RECEPTOR
DRUG-DRUG INTERACTION
PHASE-III
OPEN-LABEL
ACQUIRED-RESISTANCE
1ST-LINE TREATMENT
T790M MUTATION
EGFR MUTATIONS

Access to Document

10.1111/bcp.13534

Cite this

Vishwanathan, K., Dickinson, P. A., So, K., Thomas, K., Chen, Y-M., Carpeno, J., Dingemans, A-M. C., Kim, H. R., Kim, J-H., Krebs, M. G., Yang, J. C-H., Bui, B., Weilert, D., & Harvey, R. D. (2018). The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. British Journal of Clinical Pharmacology, 84(6), 1156-1169. https://doi.org/10.1111/bcp.13534

Vishwanathan, Karthick ; Dickinson, Paul A. ; So, Karen ; Thomas, Karen ; Chen, Yuh-Min ; Carpeno, Javier ; Dingemans, Anne-Marie C. ; Kim, Hye Ryun ; Kim, Joo-Hang ; Krebs, Matthew G. ; Yang, James Chih-Hsin ; Bui, Bui ; Weilert, Doris ; Harvey, R. Donald. / The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. In: British Journal of Clinical Pharmacology. 2018 ; Vol. 84, No. 6. pp. 1156-1169.

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title = "The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib",

keywords = "clinical pharmacology, drug metabolism, drug analysis, lung cancer, drug information, oncology, pharmacokinetics, biomarkers, drug interactions, CELL LUNG-CANCER, SYSTEMIC ANTIMYCOTICS KETOCONAZOLE, GROWTH-FACTOR RECEPTOR, DRUG-DRUG INTERACTION, PHASE-III, OPEN-LABEL, ACQUIRED-RESISTANCE, 1ST-LINE TREATMENT, T790M MUTATION, EGFR MUTATIONS",

author = "Karthick Vishwanathan and Dickinson, {Paul A.} and Karen So and Karen Thomas and Yuh-Min Chen and Javier Carpeno and Dingemans, {Anne-Marie C.} and Kim, {Hye Ryun} and Joo-Hang Kim and Krebs, {Matthew G.} and Yang, {James Chih-Hsin} and Bui Bui and Doris Weilert and Harvey, {R. Donald}",

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The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. / Vishwanathan, Karthick; Dickinson, Paul A.; So, Karen; Thomas, Karen; Chen, Yuh-Min; Carpeno, Javier; Dingemans, Anne-Marie C.; Kim, Hye Ryun; Kim, Joo-Hang; Krebs, Matthew G.; Yang, James Chih-Hsin; Bui, Bui; Weilert, Doris; Harvey, R. Donald.

In: British Journal of Clinical Pharmacology, Vol. 84, No. 6, 01.06.2018, p. 1156-1169.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib

AU - Vishwanathan, Karthick

AU - Dickinson, Paul A.

AU - So, Karen

AU - Thomas, Karen

AU - Chen, Yuh-Min

AU - Carpeno, Javier

AU - Dingemans, Anne-Marie C.

AU - Kim, Hye Ryun

AU - Kim, Joo-Hang

AU - Krebs, Matthew G.

AU - Yang, James Chih-Hsin

AU - Bui, Bui

AU - Weilert, Doris

AU - Harvey, R. Donald

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KW - pharmacokinetics

KW - biomarkers

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KW - CELL LUNG-CANCER

KW - SYSTEMIC ANTIMYCOTICS KETOCONAZOLE

KW - GROWTH-FACTOR RECEPTOR

KW - DRUG-DRUG INTERACTION

KW - PHASE-III

KW - OPEN-LABEL

KW - ACQUIRED-RESISTANCE

KW - 1ST-LINE TREATMENT

KW - T790M MUTATION

KW - EGFR MUTATIONS

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DO - 10.1111/bcp.13534

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JO - British Journal of Clinical Pharmacology

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