The effect of initiating combined antiretroviral therapy on endothelial cell activation and coagulation markers in South African HIV-infected individuals

Eefje Jong*, Susan Louw, Eric C. M. van Gorp, Joost C. M. Meijers, Hugo ten Cate, Barry F. Jacobson

*Corresponding author for this work

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Abstract

An increased incidence of venous thromboembolism (VIE) is observed in human immunodeficiency virus (HIV)-infected patients. Only a limited number of studies described the effect of combined antiretroviral therapy (cART) on coagulation markers. In a prospective cohort study in cART-naive South African HIV-infected individuals the effect of initiating cART on markers of endothelial cell activation, coagulation and natural anticoagulation was studied. These markers were compared to the reference ranges for an HIV-uninfected control population recruited from hospital staff. A venous ultrasound of both legs was performed to detect asymptomatic deep venous thrombosis (DVT). A total number of 123 HIV-infected participants were included. The patients were predominantly black and severely immuno-compromised. The CD4 cell count increased and the HIV viral load decreased significantly after the initiation of cART (p
Original languageEnglish
Pages (from-to)1228-1234
JournalThrombosis and Haemostasis
Volume104
Issue number6
DOIs
Publication statusPublished - 10 Dec 2010

Keywords

  • Coagulation factors
  • viral infection
  • venous thrombosis
  • clinical studies

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