The effect of initiating combined antiretroviral therapy on endothelial cell activation and coagulation markers in South African HIV-infected individuals

Eefje Jong; Susan Louw; Eric C. M. van Gorp; Joost C. M. Meijers; Hugo ten Cate; Barry F. Jacobson

doi:10.1160/TH10-04-0233

The effect of initiating combined antiretroviral therapy on endothelial cell activation and coagulation markers in South African HIV-infected individuals

Eefje Jong^*, Susan Louw, Eric C. M. van Gorp, Joost C. M. Meijers, Hugo ten Cate, Barry F. Jacobson

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

An increased incidence of venous thromboembolism (VIE) is observed in human immunodeficiency virus (HIV)-infected patients. Only a limited number of studies described the effect of combined antiretroviral therapy (cART) on coagulation markers. In a prospective cohort study in cART-naive South African HIV-infected individuals the effect of initiating cART on markers of endothelial cell activation, coagulation and natural anticoagulation was studied. These markers were compared to the reference ranges for an HIV-uninfected control population recruited from hospital staff. A venous ultrasound of both legs was performed to detect asymptomatic deep venous thrombosis (DVT). A total number of 123 HIV-infected participants were included. The patients were predominantly black and severely immuno-compromised. The CD4 cell count increased and the HIV viral load decreased significantly after the initiation of cART (p

Original language	English
Pages (from-to)	1228-1234
Journal	Thrombosis and Haemostasis
Volume	104
Issue number	6
DOIs	https://doi.org/10.1160/TH10-04-0233
Publication status	Published - 10 Dec 2010

Keywords

Coagulation factors
viral infection
venous thrombosis
clinical studies

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10.1160/TH10-04-0233

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abstract = "An increased incidence of venous thromboembolism (VIE) is observed in human immunodeficiency virus (HIV)-infected patients. Only a limited number of studies described the effect of combined antiretroviral therapy (cART) on coagulation markers. In a prospective cohort study in cART-naive South African HIV-infected individuals the effect of initiating cART on markers of endothelial cell activation, coagulation and natural anticoagulation was studied. These markers were compared to the reference ranges for an HIV-uninfected control population recruited from hospital staff. A venous ultrasound of both legs was performed to detect asymptomatic deep venous thrombosis (DVT). A total number of 123 HIV-infected participants were included. The patients were predominantly black and severely immuno-compromised. The CD4 cell count increased and the HIV viral load decreased significantly after the initiation of cART (p",

keywords = "Coagulation factors, viral infection, venous thrombosis, clinical studies",

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AU - Jong, Eefje

AU - Louw, Susan

AU - van Gorp, Eric C. M.

AU - Meijers, Joost C. M.

AU - ten Cate, Hugo

AU - Jacobson, Barry F.

PY - 2010/12/10

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KW - Coagulation factors

KW - viral infection

KW - venous thrombosis

KW - clinical studies

U2 - 10.1160/TH10-04-0233

DO - 10.1160/TH10-04-0233

M3 - Article

C2 - 20886182

SN - 0340-6245

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The effect of initiating combined antiretroviral therapy on endothelial cell activation and coagulation markers in South African HIV-infected individuals

Abstract

Keywords

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