The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans

M.S. Westerterp-Plantenga*, E.M.R. Kovacs

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Department of Human Biology, University of Maastricht, Maastricht, The Netherlands.

OBJECTIVE: Assessment of the effects of 2 weeks of daily administration of HCA on energy intake and satiety in overweight men and women. DESIGN: A 6-week randomized placebo-controlled single-blinded cross-over trial. SUBJECTS: consumed three times daily for 2 weeks 100 ml tomato juice (placebo) and, separated by a 2 week wash-out period, 100 ml tomato juice with 300 mg HCA.Subjects: Twelve males and 12 females (body mass index 27.5+/-2.0 kg/m(2); age 37+/-10 y). MEASUREMENTS: After 2 weeks, 24 h energy intake (EI), appetite profile, hedonics, mood and possible change in dietary restraint were assessed in the laboratory restaurant. Prevention of degradation and bio-availability was documented.RESULTS: Twenty-four-hour EI was decreased by 15-30% (P<0.05) with HCA treatment compared to placebo, without changes in the appetite profile, dietary restraint, mood, taste perception and hedonics, while body weight tended to decrease (P=0.1).CONCLUSION: HCA treatment reduced 24 h EI in humans while satiety was sustained.

Publication Types:
Clinical Trial
Randomized Controlled Trial
Original languageEnglish
Pages (from-to)870-872
Number of pages3
JournalInternational Journal of Obesity
Issue number6
Publication statusPublished - 1 Jan 2002

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