The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers

D. Starkov*, B. Vermorken, T.S. Van Dooren, L. Van Stiphout, M. Janssen, M. Pleshkov, N. Guinand, A.P. Fornos, V. Van Rompaey, H. Kingma, R. van de Berg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades.</p>Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements.</p>Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p < 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p <= 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p <= 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004).</p>Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades.</p>
Original languageEnglish
Article number729081
Number of pages10
JournalFrontiers in Neurology
Volume12
DOIs
Publication statusPublished - 22 Sep 2021

Keywords

  • vestibular ocular reflex
  • video head impulse test (vHIT)
  • suppression head impulse paradigm
  • active head impulse
  • passive head impulse
  • inward head impulse
  • outward head impulse
  • UNILATERAL VESTIBULAR LOSS
  • OCULAR REFLEX
  • VIDEO
  • VOR
  • OUTWARD

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