The effect of clinical decision support on adherence to thrombosis prophylaxis guidelines in medical patients; A single center experience

Pieter Eijgenraam*, Nathalie Meertens, Rene van den Ham, Hugo ten Cate, Arina Hoek - ten Cate

*Corresponding author for this work

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Introduction: Venous thromboembolism (VTE) is an underestimated health problem. The administration of low molecular weight heparins (LMWH) to the appropriate patients dramatically decreases VTE incidence. Clinical decision support (CDS) might contribute to thrombosis prophylaxis guideline adherence. Methods: A computerized integrated risk score programwas used to estimate VTE and bleeding risk of nonsurgical patients. A VTE risk score of >= 4 resulted in an advice to administer LMWH. We selected 64 medical patients before the introduction of CDS (T0) and 64 patients after the introduction (T1). We compared guideline compliance between these groups using chi(2) tests. Results: No difference between groups was found; Adherence to the guidelines at T0 was 59.4%, the same percentage of 59.4% was found at T1. To evaluate the effect of the introduction of CDS in terms of under and overtreatment we compared the prevalence of over and under treatment at T1 and T0. The OR for receiving under treatment at T1 compared to T0 is 0.48 (95% CI: 0.18-1.30), p= 0.14. The OR for overtreatment at T1 compared to T0 is 1.66 (95% CI: 0.74-3.73), p = 0.22 Conclusion: We found no improvement in guideline adherence towards anti thrombotic prophylaxis in medical patients after the introduction of CDS in this pilot study. There was however a non-significant shift towards over treatment. Possible explanations for these results are the increased awareness of the risk for thromboembolism induced by the study, suboptimal use of CDS and deviation fromCDS advice caused by patient's preferences.
Original languageEnglish
Pages (from-to)464-471
JournalThrombosis Research
Issue number3
Publication statusPublished - Mar 2015


  • Clinical decision support
  • Guideline adherence
  • Thrombosis
  • Prophylaxis

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