The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study

T. J. A. van Nijnatten*, L. P. T. van Tiel, A. C. Voogd, C. G. M. Groothuis-Oudshoorn, S. Siesling, M. B. I. Lobbes

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Purpose To evaluate the effect of breast MRI on overall survival (OS) and disease-free survival (DFS) of patients with invasive breast cancer in the Netherlands. Methods We selected all women from the Netherlands Cancer Registry diagnosed with invasive breast cancer (a) between 2011 and 2013 for the OS-cohort and (b) in the first quarter of 2012 for the DFS-cohort. The study population was subdivided into an MRI and non-MRI group. In addition, subgroups were created according to breast cancer subtype: invasive carcinoma of no special type (NST) versus invasive lobular carcinoma (ILC). OS and DFS were compared between the MRI and non-MRI group using the Kaplan-Meier method and the log-rank test. Cox proportional hazard regression analysis was performed to estimate hazard ratios (HR) with a 95% confidence interval (CI). To account for missing data, multiple imputation was performed. Results Of the 31,756 patients included in the OS-cohort (70% non-MRI and 30% MRI), 27,752 (87%) were diagnosed with invasive carcinoma NST and 4004 (13%) with ILC. Of the 2464 patients included in the DFS-cohort (72% non-MRI and 28% MRI), 2161 (88%) were diagnosed with invasive carcinoma NST and 303 (12%) with ILC. The distribution of breast MRI use was significantly lower over different age categories, from 49.0% aged <50 to 16.5% aged > 70. Multivariable Cox regression showed that breast MRI was not significantly associated with OS overall (HR 0.91, 95%-CI 0.74-1.11,p = 0.35), nor in the different histological subtypes. Multivariable Cox regression analysis showed that breast MRI was also not significantly associated with DFS (HR 1.16, 95%-CI 0.81-1.67), nor in the different histological subtypes. Conclusion Use of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery.

Original languageEnglish
Pages (from-to)951-963
Number of pages13
JournalBreast Cancer Research and Treatment
Volume184
Issue number3
Early online date15 Sep 2020
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Breast cancer
  • Magnetic resonance imaging
  • Disease-free survival
  • Overall survival
  • OUTCOMES
  • CARCINOMA
  • WOMEN

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