The ECG Belt for CRT response trial: Design and clinical protocol

John Rickard*, Kevin Jackson, Mauro Biffi, Kevin Vernooy, Alan Bank, Jeff Cerkvenik, Subham Ghosh, Michael R. Gold

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

The ECG Belt for CRT response trial is designed to test the hypothesis that in patients traditionally less likely to respond to cardiac resynchronization therapy (CRT), an individualized approach utilizing the electrocardiogram (ECG) Belt to guide lead placement, vector selection, and device programming is superior to current standard of care. The ECG Belt is a noninvasive mapping technology designed to measure beat by beat electrical activation of the left ventricle by utilizing unipolar measurements from multiple ECG electrodes on the body surface. The ECG Belt for CRT response trial is a multicenter, prospective, randomized, investigational pre-market research study conducted at 48 centers in the United States, Canada, and Europe and will randomize approximately 400 subjects. The trial has three arms (enrollment will be 2:1:1, respectively): utilization of the Belt to guide implant as well as postimplant programming, utilizing the Belt to guide postimplant programming alone, and a non-Belt control arm. AdaptivCRT will be an option in the treatment arm but not the control arms. The primary endpoint is change in left ventricular end-systolic volume between preimplant and at 6 months. This paper describes the design and analytic plan for the trial.

Original languageEnglish
Pages (from-to)1063-1071
Number of pages9
JournalPacing and Clinical Electrophysiology
Volume43
Issue number10
Early online date1 Sept 2020
DOIs
Publication statusPublished - Oct 2020

Keywords

  • cardiac resynchronization therapy
  • electrocardiographic imaging
  • CARDIAC-RESYNCHRONIZATION THERAPY
  • VENTRICULAR LEAD PLACEMENT
  • HEART-FAILURE PATIENTS
  • BUNDLE-BRANCH BLOCK
  • OPTIMIZATION
  • ACTIVATION

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