The dynamic mechanical viscoelastic properties of the temporomandibular joint disc: The role of collagen and elastin fibers from a perspective of polymer dynamics

S Fazaeli, Samaneh Ghazanfari, Fereshteh Mirahmadi, Vincent Everts, Theodoor H Smit, J.H. Koolestra

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The temporomandibular joint disc is a structure, characterized as heterogeneous fibrocartilage, and is composed of macromolecular biopolymers. Despite a large body of characterization studies, the contribution of matrix biopolymers on the dynamic viscoelastic behavior of the disc is poorly understood. Given the high permeability and low concentration of glycosaminoglycans in the disc, it has been suggested that poro-elastic behavior can be neglected and that the intrinsic viscoelastic nature of solid matrix plays a dominant role in governing its time-dependent behavior. This study attempts to quantify the contribution of collagen and elastin fibers to the viscoelastic properties of the disc. Using collagenase and elastase, we perturbed the collagen and elastin fibrillar network in porcine temporomandibular joint discs and investigated the changes of dynamic viscoelastic properties in five different regions of the disc. Following both treatments, the storage and loss moduli of these regions were reduced dramatically up to the point that the tissue was no longer mechanically heterogeneous. However, the proportion of changes in storage and loss moduli were different for each treatment, reflected in the decrease and increase of the loss tangent for collagenase and elastase treated discs, respectively. The reduction of storage and loss moduli of the disc correlated with a decrease of biopolymer length. The present study indicates that the compositional and structural changes of collagen and elastin fibers alter the viscoelastic properties of the disc consistent with polymer dynamics.
Original languageEnglish
Article number103406
Number of pages9
JournalJournal of the mechanical behavior of biomedical materials
Volume100
DOIs
Publication statusPublished - Dec 2019

Keywords

  • ARTICULAR-CARTILAGE
  • Collagen fiber
  • Dynamic mechanical properties
  • EXPERIMENTAL-VERIFICATION
  • Elastin fiber
  • Enzymatic degradation
  • FLOW-INDEPENDENT VISCOELASTICITY
  • INTERNAL DERANGEMENT
  • INTERSTITIAL FLUID PRESSURIZATION
  • INTRAARTICULAR DISC
  • INTRINSIC MATRIX VISCOELASTICITY
  • RHEUMATOID-ARTHRITIS
  • STRESS-RELAXATION
  • Temporomandibular joint disc
  • UNCONFINED COMPRESSION

Cite this

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title = "The dynamic mechanical viscoelastic properties of the temporomandibular joint disc: The role of collagen and elastin fibers from a perspective of polymer dynamics",
abstract = "The temporomandibular joint disc is a structure, characterized as heterogeneous fibrocartilage, and is composed of macromolecular biopolymers. Despite a large body of characterization studies, the contribution of matrix biopolymers on the dynamic viscoelastic behavior of the disc is poorly understood. Given the high permeability and low concentration of glycosaminoglycans in the disc, it has been suggested that poro-elastic behavior can be neglected and that the intrinsic viscoelastic nature of solid matrix plays a dominant role in governing its time-dependent behavior. This study attempts to quantify the contribution of collagen and elastin fibers to the viscoelastic properties of the disc. Using collagenase and elastase, we perturbed the collagen and elastin fibrillar network in porcine temporomandibular joint discs and investigated the changes of dynamic viscoelastic properties in five different regions of the disc. Following both treatments, the storage and loss moduli of these regions were reduced dramatically up to the point that the tissue was no longer mechanically heterogeneous. However, the proportion of changes in storage and loss moduli were different for each treatment, reflected in the decrease and increase of the loss tangent for collagenase and elastase treated discs, respectively. The reduction of storage and loss moduli of the disc correlated with a decrease of biopolymer length. The present study indicates that the compositional and structural changes of collagen and elastin fibers alter the viscoelastic properties of the disc consistent with polymer dynamics.",
keywords = "ARTICULAR-CARTILAGE, Collagen fiber, Dynamic mechanical properties, EXPERIMENTAL-VERIFICATION, Elastin fiber, Enzymatic degradation, FLOW-INDEPENDENT VISCOELASTICITY, INTERNAL DERANGEMENT, INTERSTITIAL FLUID PRESSURIZATION, INTRAARTICULAR DISC, INTRINSIC MATRIX VISCOELASTICITY, RHEUMATOID-ARTHRITIS, STRESS-RELAXATION, Temporomandibular joint disc, UNCONFINED COMPRESSION",
author = "S Fazaeli and Samaneh Ghazanfari and Fereshteh Mirahmadi and Vincent Everts and Smit, {Theodoor H} and J.H. Koolestra",
year = "2019",
month = "12",
doi = "10.1016/j.jmbbm.2019.103406",
language = "English",
volume = "100",
journal = "Journal of the mechanical behavior of biomedical materials",
issn = "1751-6161",
publisher = "Elsevier",

}

The dynamic mechanical viscoelastic properties of the temporomandibular joint disc: The role of collagen and elastin fibers from a perspective of polymer dynamics. / Fazaeli, S ; Ghazanfari, Samaneh; Mirahmadi, Fereshteh ; Everts, Vincent; Smit, Theodoor H ; Koolestra, J.H. .

In: Journal of the mechanical behavior of biomedical materials, Vol. 100, 103406, 12.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The dynamic mechanical viscoelastic properties of the temporomandibular joint disc: The role of collagen and elastin fibers from a perspective of polymer dynamics

AU - Fazaeli, S

AU - Ghazanfari, Samaneh

AU - Mirahmadi, Fereshteh

AU - Everts, Vincent

AU - Smit, Theodoor H

AU - Koolestra, J.H.

PY - 2019/12

Y1 - 2019/12

N2 - The temporomandibular joint disc is a structure, characterized as heterogeneous fibrocartilage, and is composed of macromolecular biopolymers. Despite a large body of characterization studies, the contribution of matrix biopolymers on the dynamic viscoelastic behavior of the disc is poorly understood. Given the high permeability and low concentration of glycosaminoglycans in the disc, it has been suggested that poro-elastic behavior can be neglected and that the intrinsic viscoelastic nature of solid matrix plays a dominant role in governing its time-dependent behavior. This study attempts to quantify the contribution of collagen and elastin fibers to the viscoelastic properties of the disc. Using collagenase and elastase, we perturbed the collagen and elastin fibrillar network in porcine temporomandibular joint discs and investigated the changes of dynamic viscoelastic properties in five different regions of the disc. Following both treatments, the storage and loss moduli of these regions were reduced dramatically up to the point that the tissue was no longer mechanically heterogeneous. However, the proportion of changes in storage and loss moduli were different for each treatment, reflected in the decrease and increase of the loss tangent for collagenase and elastase treated discs, respectively. The reduction of storage and loss moduli of the disc correlated with a decrease of biopolymer length. The present study indicates that the compositional and structural changes of collagen and elastin fibers alter the viscoelastic properties of the disc consistent with polymer dynamics.

AB - The temporomandibular joint disc is a structure, characterized as heterogeneous fibrocartilage, and is composed of macromolecular biopolymers. Despite a large body of characterization studies, the contribution of matrix biopolymers on the dynamic viscoelastic behavior of the disc is poorly understood. Given the high permeability and low concentration of glycosaminoglycans in the disc, it has been suggested that poro-elastic behavior can be neglected and that the intrinsic viscoelastic nature of solid matrix plays a dominant role in governing its time-dependent behavior. This study attempts to quantify the contribution of collagen and elastin fibers to the viscoelastic properties of the disc. Using collagenase and elastase, we perturbed the collagen and elastin fibrillar network in porcine temporomandibular joint discs and investigated the changes of dynamic viscoelastic properties in five different regions of the disc. Following both treatments, the storage and loss moduli of these regions were reduced dramatically up to the point that the tissue was no longer mechanically heterogeneous. However, the proportion of changes in storage and loss moduli were different for each treatment, reflected in the decrease and increase of the loss tangent for collagenase and elastase treated discs, respectively. The reduction of storage and loss moduli of the disc correlated with a decrease of biopolymer length. The present study indicates that the compositional and structural changes of collagen and elastin fibers alter the viscoelastic properties of the disc consistent with polymer dynamics.

KW - ARTICULAR-CARTILAGE

KW - Collagen fiber

KW - Dynamic mechanical properties

KW - EXPERIMENTAL-VERIFICATION

KW - Elastin fiber

KW - Enzymatic degradation

KW - FLOW-INDEPENDENT VISCOELASTICITY

KW - INTERNAL DERANGEMENT

KW - INTERSTITIAL FLUID PRESSURIZATION

KW - INTRAARTICULAR DISC

KW - INTRINSIC MATRIX VISCOELASTICITY

KW - RHEUMATOID-ARTHRITIS

KW - STRESS-RELAXATION

KW - Temporomandibular joint disc

KW - UNCONFINED COMPRESSION

U2 - 10.1016/j.jmbbm.2019.103406

DO - 10.1016/j.jmbbm.2019.103406

M3 - Article

VL - 100

JO - Journal of the mechanical behavior of biomedical materials

JF - Journal of the mechanical behavior of biomedical materials

SN - 1751-6161

M1 - 103406

ER -