The Dutch Measure for quantification of Treatment Resistance in Depression (DM-TRD): an extension of the Maudsley Staging Method

Frenk P.M.L. Peeters, Henricus G Ruhe, Marieke Wichers, Latifa Abidi, Karin Kaub, H Josephine van der Lande, Jan Spijker, Marcus J H Huibers, Aart H Schene

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Treatment resistant depression (TRD) is common in daily practice. An empirical, widely accepted and applicable measure to quantify TRD is lacking. Previously, the Maudsley Staging Method (MSM) showed good validity. We aimed to improve the MSM by refining and extending its items resulting in the Dutch Measure for quantification of TRD (DM-TRD).

METHODS: In addition to duration, severity and failed treatments in the current depressive episode, we added items for functional impairment, comorbid anxiety, personality disorders and psychosocial stressors. We extended the augmentation section and added items for failed psychotherapy and intensified treatment. We examined psychometric properties of the DM-TRD and tested prediction of future depressive symptoms and remission after 16 weeks in 274 (DSM-IV) depressed in- and outpatients entering naturalistic treatment.

RESULTS: The DM-TRD showed excellent inter-/intra-rater reliability. Higher scores were associated with more symptoms and less remission during follow-up. The DM-TRD outperformed the MSM in prediction of future depressive symptomatology. Remission was predicted equally well by both measures. Longer duration of the current episode, larger functional impairment and larger baseline symptom severity were the strongest predictors of symptomatology at follow-up. Longer duration and larger functional impairment were negatively associated with remission.

LIMITATIONS: Longer follow-up could have increased predictive power. Addition of items for somatic co-morbidity, childhood adversity and psychotic features must be investigated further.

CONCLUSION: The DM-TRD has excellent psychometric properties and better predictive validity for clinical outcome than other sophisticated measure published to date. Its use in clinical practice and research will improve treatment planning in TRD-patients.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalJournal of Affective Disorders
Volume205
DOIs
Publication statusPublished - 15 Nov 2016

Keywords

  • Treatment resistant depression
  • Major depressive disorder
  • Measurement
  • Profiling
  • BIPOLAR SPECTRUM FEATURES
  • MAJOR DEPRESSION
  • INTERPERSONAL PSYCHOTHERAPY
  • PERSONALITY-DISORDERS
  • ANXIETY DISORDERS
  • COGNITIVE THERAPY
  • ANTIDEPRESSANTS
  • PHARMACOTHERAPY
  • AUGMENTATION
  • MODERATORS

Cite this

Peeters, Frenk P.M.L. ; Ruhe, Henricus G ; Wichers, Marieke ; Abidi, Latifa ; Kaub, Karin ; van der Lande, H Josephine ; Spijker, Jan ; Huibers, Marcus J H ; Schene, Aart H. / The Dutch Measure for quantification of Treatment Resistance in Depression (DM-TRD) : an extension of the Maudsley Staging Method. In: Journal of Affective Disorders. 2016 ; Vol. 205. pp. 365-371.
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abstract = "BACKGROUND: Treatment resistant depression (TRD) is common in daily practice. An empirical, widely accepted and applicable measure to quantify TRD is lacking. Previously, the Maudsley Staging Method (MSM) showed good validity. We aimed to improve the MSM by refining and extending its items resulting in the Dutch Measure for quantification of TRD (DM-TRD).METHODS: In addition to duration, severity and failed treatments in the current depressive episode, we added items for functional impairment, comorbid anxiety, personality disorders and psychosocial stressors. We extended the augmentation section and added items for failed psychotherapy and intensified treatment. We examined psychometric properties of the DM-TRD and tested prediction of future depressive symptoms and remission after 16 weeks in 274 (DSM-IV) depressed in- and outpatients entering naturalistic treatment.RESULTS: The DM-TRD showed excellent inter-/intra-rater reliability. Higher scores were associated with more symptoms and less remission during follow-up. The DM-TRD outperformed the MSM in prediction of future depressive symptomatology. Remission was predicted equally well by both measures. Longer duration of the current episode, larger functional impairment and larger baseline symptom severity were the strongest predictors of symptomatology at follow-up. Longer duration and larger functional impairment were negatively associated with remission.LIMITATIONS: Longer follow-up could have increased predictive power. Addition of items for somatic co-morbidity, childhood adversity and psychotic features must be investigated further.CONCLUSION: The DM-TRD has excellent psychometric properties and better predictive validity for clinical outcome than other sophisticated measure published to date. Its use in clinical practice and research will improve treatment planning in TRD-patients.",
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author = "Peeters, {Frenk P.M.L.} and Ruhe, {Henricus G} and Marieke Wichers and Latifa Abidi and Karin Kaub and {van der Lande}, {H Josephine} and Jan Spijker and Huibers, {Marcus J H} and Schene, {Aart H}",
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The Dutch Measure for quantification of Treatment Resistance in Depression (DM-TRD) : an extension of the Maudsley Staging Method. / Peeters, Frenk P.M.L.; Ruhe, Henricus G; Wichers, Marieke; Abidi, Latifa; Kaub, Karin; van der Lande, H Josephine; Spijker, Jan; Huibers, Marcus J H; Schene, Aart H.

In: Journal of Affective Disorders, Vol. 205, 15.11.2016, p. 365-371.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The Dutch Measure for quantification of Treatment Resistance in Depression (DM-TRD)

T2 - an extension of the Maudsley Staging Method

AU - Peeters, Frenk P.M.L.

AU - Ruhe, Henricus G

AU - Wichers, Marieke

AU - Abidi, Latifa

AU - Kaub, Karin

AU - van der Lande, H Josephine

AU - Spijker, Jan

AU - Huibers, Marcus J H

AU - Schene, Aart H

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016/11/15

Y1 - 2016/11/15

N2 - BACKGROUND: Treatment resistant depression (TRD) is common in daily practice. An empirical, widely accepted and applicable measure to quantify TRD is lacking. Previously, the Maudsley Staging Method (MSM) showed good validity. We aimed to improve the MSM by refining and extending its items resulting in the Dutch Measure for quantification of TRD (DM-TRD).METHODS: In addition to duration, severity and failed treatments in the current depressive episode, we added items for functional impairment, comorbid anxiety, personality disorders and psychosocial stressors. We extended the augmentation section and added items for failed psychotherapy and intensified treatment. We examined psychometric properties of the DM-TRD and tested prediction of future depressive symptoms and remission after 16 weeks in 274 (DSM-IV) depressed in- and outpatients entering naturalistic treatment.RESULTS: The DM-TRD showed excellent inter-/intra-rater reliability. Higher scores were associated with more symptoms and less remission during follow-up. The DM-TRD outperformed the MSM in prediction of future depressive symptomatology. Remission was predicted equally well by both measures. Longer duration of the current episode, larger functional impairment and larger baseline symptom severity were the strongest predictors of symptomatology at follow-up. Longer duration and larger functional impairment were negatively associated with remission.LIMITATIONS: Longer follow-up could have increased predictive power. Addition of items for somatic co-morbidity, childhood adversity and psychotic features must be investigated further.CONCLUSION: The DM-TRD has excellent psychometric properties and better predictive validity for clinical outcome than other sophisticated measure published to date. Its use in clinical practice and research will improve treatment planning in TRD-patients.

AB - BACKGROUND: Treatment resistant depression (TRD) is common in daily practice. An empirical, widely accepted and applicable measure to quantify TRD is lacking. Previously, the Maudsley Staging Method (MSM) showed good validity. We aimed to improve the MSM by refining and extending its items resulting in the Dutch Measure for quantification of TRD (DM-TRD).METHODS: In addition to duration, severity and failed treatments in the current depressive episode, we added items for functional impairment, comorbid anxiety, personality disorders and psychosocial stressors. We extended the augmentation section and added items for failed psychotherapy and intensified treatment. We examined psychometric properties of the DM-TRD and tested prediction of future depressive symptoms and remission after 16 weeks in 274 (DSM-IV) depressed in- and outpatients entering naturalistic treatment.RESULTS: The DM-TRD showed excellent inter-/intra-rater reliability. Higher scores were associated with more symptoms and less remission during follow-up. The DM-TRD outperformed the MSM in prediction of future depressive symptomatology. Remission was predicted equally well by both measures. Longer duration of the current episode, larger functional impairment and larger baseline symptom severity were the strongest predictors of symptomatology at follow-up. Longer duration and larger functional impairment were negatively associated with remission.LIMITATIONS: Longer follow-up could have increased predictive power. Addition of items for somatic co-morbidity, childhood adversity and psychotic features must be investigated further.CONCLUSION: The DM-TRD has excellent psychometric properties and better predictive validity for clinical outcome than other sophisticated measure published to date. Its use in clinical practice and research will improve treatment planning in TRD-patients.

KW - Treatment resistant depression

KW - Major depressive disorder

KW - Measurement

KW - Profiling

KW - BIPOLAR SPECTRUM FEATURES

KW - MAJOR DEPRESSION

KW - INTERPERSONAL PSYCHOTHERAPY

KW - PERSONALITY-DISORDERS

KW - ANXIETY DISORDERS

KW - COGNITIVE THERAPY

KW - ANTIDEPRESSANTS

KW - PHARMACOTHERAPY

KW - AUGMENTATION

KW - MODERATORS

U2 - 10.1016/j.jad.2016.08.019

DO - 10.1016/j.jad.2016.08.019

M3 - Article

C2 - 27568174

VL - 205

SP - 365

EP - 371

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -