The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited.

C.I. De Bie, T.Z. Hummel, A. Kindermann, F.T. Kokke, G.M. Damen, C.M. Kneepkens, P.F. Van Rheenen, J.J. Schweizer, J.H. Hoekstra, O.F. Norbruis, A.T.W.E. Tjon, A.C.E. Vreugdenhil, J.M. Deckers Kocken, C.F. Gijsbers, J.C. Escher, L. De Ridder

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Abstract

Background Infliximab is effective for induction and maintenance of remission in children with moderately to severely active Crohn's disease (CD). Aim To evaluate the long-term efficacy of infliximab treatment in paediatric CD. Methods In this observational, multicentre study, all paediatric CD patients in The Netherlands treated with infliximab from October 1992 to November 2009 and with minimal follow-up of 3 months since start of infliximab, were studied. Results One hundred and fifty-two CD patients [81M; median age at start of infliximab 15.0 years (IQR 13.1-16.4)] received a median number of 10.5 infliximab infusions (IQR 6-21). Median follow-up after start of infliximab was 25 months (IQR 13-40). Kaplan-Meier analysis showed that the cumulative probability of losing response to infliximab in patients who initially required repeated infusions was 13%, 40% and 50% after 1, 3 and 5 years, respectively. Seventy-four patients (49%) needed dose adjustments, with a median time to any adjustment of 6 months. Conclusions Duration of effect of infliximab is limited as 50% of patients on infliximab maintenance treatment lose their therapeutic response after 5 years. Dose adjustments after start of infliximab are frequently needed to regain therapeutic benefit. These findings emphasise the need for effective, long-term treatment strategies for paediatric CD.
Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalAlimentary Pharmacology & Therapeutics
Volume33
Issue number2
DOIs
Publication statusPublished - 15 Jan 2011

Keywords

  • INFLAMMATORY-BOWEL-DISEASE
  • SHORT-TERM
  • THERAPY
  • CHILDREN
  • ANTIBODY
  • SAFETY
  • EFFICACY
  • COHORT
  • NETHERLANDS
  • EXPERIENCE

Cite this

De Bie, C. I., Hummel, T. Z., Kindermann, A., Kokke, F. T., Damen, G. M., Kneepkens, C. M., ... De Ridder, L. (2011). The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited. Alimentary Pharmacology & Therapeutics, 33(2), 243-250. https://doi.org/10.1111/j.1365-2036.2010.04507.x
De Bie, C.I. ; Hummel, T.Z. ; Kindermann, A. ; Kokke, F.T. ; Damen, G.M. ; Kneepkens, C.M. ; Van Rheenen, P.F. ; Schweizer, J.J. ; Hoekstra, J.H. ; Norbruis, O.F. ; Tjon, A.T.W.E. ; Vreugdenhil, A.C.E. ; Deckers Kocken, J.M. ; Gijsbers, C.F. ; Escher, J.C. ; De Ridder, L. / The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited. In: Alimentary Pharmacology & Therapeutics. 2011 ; Vol. 33, No. 2. pp. 243-250.
@article{aaf983dd28844d609ab84b487018ae87,
title = "The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited.",
abstract = "Background Infliximab is effective for induction and maintenance of remission in children with moderately to severely active Crohn's disease (CD). Aim To evaluate the long-term efficacy of infliximab treatment in paediatric CD. Methods In this observational, multicentre study, all paediatric CD patients in The Netherlands treated with infliximab from October 1992 to November 2009 and with minimal follow-up of 3 months since start of infliximab, were studied. Results One hundred and fifty-two CD patients [81M; median age at start of infliximab 15.0 years (IQR 13.1-16.4)] received a median number of 10.5 infliximab infusions (IQR 6-21). Median follow-up after start of infliximab was 25 months (IQR 13-40). Kaplan-Meier analysis showed that the cumulative probability of losing response to infliximab in patients who initially required repeated infusions was 13{\%}, 40{\%} and 50{\%} after 1, 3 and 5 years, respectively. Seventy-four patients (49{\%}) needed dose adjustments, with a median time to any adjustment of 6 months. Conclusions Duration of effect of infliximab is limited as 50{\%} of patients on infliximab maintenance treatment lose their therapeutic response after 5 years. Dose adjustments after start of infliximab are frequently needed to regain therapeutic benefit. These findings emphasise the need for effective, long-term treatment strategies for paediatric CD.",
keywords = "INFLAMMATORY-BOWEL-DISEASE, SHORT-TERM, THERAPY, CHILDREN, ANTIBODY, SAFETY, EFFICACY, COHORT, NETHERLANDS, EXPERIENCE",
author = "{De Bie}, C.I. and T.Z. Hummel and A. Kindermann and F.T. Kokke and G.M. Damen and C.M. Kneepkens and {Van Rheenen}, P.F. and J.J. Schweizer and J.H. Hoekstra and O.F. Norbruis and A.T.W.E. Tjon and A.C.E. Vreugdenhil and {Deckers Kocken}, J.M. and C.F. Gijsbers and J.C. Escher and {De Ridder}, L.",
year = "2011",
month = "1",
day = "15",
doi = "10.1111/j.1365-2036.2010.04507.x",
language = "English",
volume = "33",
pages = "243--250",
journal = "Alimentary Pharmacology & Therapeutics",
issn = "0269-2813",
publisher = "Wiley",
number = "2",

}

De Bie, CI, Hummel, TZ, Kindermann, A, Kokke, FT, Damen, GM, Kneepkens, CM, Van Rheenen, PF, Schweizer, JJ, Hoekstra, JH, Norbruis, OF, Tjon, ATWE, Vreugdenhil, ACE, Deckers Kocken, JM, Gijsbers, CF, Escher, JC & De Ridder, L 2011, 'The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited.', Alimentary Pharmacology & Therapeutics, vol. 33, no. 2, pp. 243-250. https://doi.org/10.1111/j.1365-2036.2010.04507.x

The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited. / De Bie, C.I.; Hummel, T.Z.; Kindermann, A.; Kokke, F.T.; Damen, G.M.; Kneepkens, C.M.; Van Rheenen, P.F.; Schweizer, J.J.; Hoekstra, J.H.; Norbruis, O.F.; Tjon, A.T.W.E.; Vreugdenhil, A.C.E.; Deckers Kocken, J.M.; Gijsbers, C.F.; Escher, J.C.; De Ridder, L.

In: Alimentary Pharmacology & Therapeutics, Vol. 33, No. 2, 15.01.2011, p. 243-250.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited.

AU - De Bie, C.I.

AU - Hummel, T.Z.

AU - Kindermann, A.

AU - Kokke, F.T.

AU - Damen, G.M.

AU - Kneepkens, C.M.

AU - Van Rheenen, P.F.

AU - Schweizer, J.J.

AU - Hoekstra, J.H.

AU - Norbruis, O.F.

AU - Tjon, A.T.W.E.

AU - Vreugdenhil, A.C.E.

AU - Deckers Kocken, J.M.

AU - Gijsbers, C.F.

AU - Escher, J.C.

AU - De Ridder, L.

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Background Infliximab is effective for induction and maintenance of remission in children with moderately to severely active Crohn's disease (CD). Aim To evaluate the long-term efficacy of infliximab treatment in paediatric CD. Methods In this observational, multicentre study, all paediatric CD patients in The Netherlands treated with infliximab from October 1992 to November 2009 and with minimal follow-up of 3 months since start of infliximab, were studied. Results One hundred and fifty-two CD patients [81M; median age at start of infliximab 15.0 years (IQR 13.1-16.4)] received a median number of 10.5 infliximab infusions (IQR 6-21). Median follow-up after start of infliximab was 25 months (IQR 13-40). Kaplan-Meier analysis showed that the cumulative probability of losing response to infliximab in patients who initially required repeated infusions was 13%, 40% and 50% after 1, 3 and 5 years, respectively. Seventy-four patients (49%) needed dose adjustments, with a median time to any adjustment of 6 months. Conclusions Duration of effect of infliximab is limited as 50% of patients on infliximab maintenance treatment lose their therapeutic response after 5 years. Dose adjustments after start of infliximab are frequently needed to regain therapeutic benefit. These findings emphasise the need for effective, long-term treatment strategies for paediatric CD.

AB - Background Infliximab is effective for induction and maintenance of remission in children with moderately to severely active Crohn's disease (CD). Aim To evaluate the long-term efficacy of infliximab treatment in paediatric CD. Methods In this observational, multicentre study, all paediatric CD patients in The Netherlands treated with infliximab from October 1992 to November 2009 and with minimal follow-up of 3 months since start of infliximab, were studied. Results One hundred and fifty-two CD patients [81M; median age at start of infliximab 15.0 years (IQR 13.1-16.4)] received a median number of 10.5 infliximab infusions (IQR 6-21). Median follow-up after start of infliximab was 25 months (IQR 13-40). Kaplan-Meier analysis showed that the cumulative probability of losing response to infliximab in patients who initially required repeated infusions was 13%, 40% and 50% after 1, 3 and 5 years, respectively. Seventy-four patients (49%) needed dose adjustments, with a median time to any adjustment of 6 months. Conclusions Duration of effect of infliximab is limited as 50% of patients on infliximab maintenance treatment lose their therapeutic response after 5 years. Dose adjustments after start of infliximab are frequently needed to regain therapeutic benefit. These findings emphasise the need for effective, long-term treatment strategies for paediatric CD.

KW - INFLAMMATORY-BOWEL-DISEASE

KW - SHORT-TERM

KW - THERAPY

KW - CHILDREN

KW - ANTIBODY

KW - SAFETY

KW - EFFICACY

KW - COHORT

KW - NETHERLANDS

KW - EXPERIENCE

U2 - 10.1111/j.1365-2036.2010.04507.x

DO - 10.1111/j.1365-2036.2010.04507.x

M3 - Article

VL - 33

SP - 243

EP - 250

JO - Alimentary Pharmacology & Therapeutics

JF - Alimentary Pharmacology & Therapeutics

SN - 0269-2813

IS - 2

ER -