The Driving Regulators of the Connectivity Protein Network of Brain Malignancies

A. Tahmassebi; K. Pinker-Domenig; G. Wengert; M. Lobbes; A. Stadlbauer; N.C. Wildburger; F.J. Romero; D.P. Morales; E. Castillo; A. Garcia; G. Botella; A. Meyer-Base

doi:10.1117/12.2263554

The Driving Regulators of the Connectivity Protein Network of Brain Malignancies

A. Tahmassebi^*, K. Pinker-Domenig, G. Wengert, M. Lobbes, A. Stadlbauer, N.C. Wildburger, F.J. Romero, D.P. Morales, E. Castillo, A. Garcia, G. Botella, A. Meyer-Base

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

Abstract

An important problem in modern therapeutics at the proteomic level remains to identify therapeutic targets in a plentitude of high-throughput data from experiments relevant to a variety of diseases. This paper presents the application of novel modern control concepts, such as pinning controllability and observability applied to the glioma cancer stem cells (GSCs) protein graph network with known and novel association to glioblastoma (GBM). The theoretical frameworks provides us with the minimal number of "driver nodes", which are necessary, and their location to determine the full control over the obtained graph network in order to provide a change in the network's dynamics from an initial state (disease) to a desired state (non-disease). The achieved results will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, to design and test novel therapeutic solutions.

Original language	English
Title of host publication	SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XIV
Publisher	SPIE-INT SOC OPTICAL ENGINEERING
Number of pages	8
ISBN (Print)	9781510609341
DOIs	https://doi.org/10.1117/12.2263554
Publication status	Published - 2017
Event	Conference on Smart Biomedical and Physiological Sensor Technology XIV: At SPIE Commercial + Scientific Sensing and Imaging - Anaheim, United States Duration: 9 Apr 2017 → 10 Apr 2017 https://www.proceedings.com/spie10216.html

Publication series

Series	Proceedings of SPIE
Volume	10216
ISSN	0277-786X

Conference

Conference	Conference on Smart Biomedical and Physiological Sensor Technology XIV
Country/Territory	United States
City	Anaheim
Period	9/04/17 → 10/04/17
Internet address	https://www.proceedings.com/spie10216.html

Keywords

Graph theory
nonlinear dynamics
dynamic graph
pathway analysis and control
glioma cancer stem cells

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10.1117/12.2263554

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Tahmassebi, A., Pinker-Domenig, K., Wengert, G., Lobbes, M., Stadlbauer, A., Wildburger, N. C., Romero, F. J., Morales, D. P., Castillo, E., Garcia, A., Botella, G., & Meyer-Base, A. (2017). The Driving Regulators of the Connectivity Protein Network of Brain Malignancies. In SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XIV Article 1021605 SPIE-INT SOC OPTICAL ENGINEERING. https://doi.org/10.1117/12.2263554

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abstract = "An important problem in modern therapeutics at the proteomic level remains to identify therapeutic targets in a plentitude of high-throughput data from experiments relevant to a variety of diseases. This paper presents the application of novel modern control concepts, such as pinning controllability and observability applied to the glioma cancer stem cells (GSCs) protein graph network with known and novel association to glioblastoma (GBM). The theoretical frameworks provides us with the minimal number of {"}driver nodes{"}, which are necessary, and their location to determine the full control over the obtained graph network in order to provide a change in the network's dynamics from an initial state (disease) to a desired state (non-disease). The achieved results will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, to design and test novel therapeutic solutions.",

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author = "A. Tahmassebi and K. Pinker-Domenig and G. Wengert and M. Lobbes and A. Stadlbauer and N.C. Wildburger and F.J. Romero and D.P. Morales and E. Castillo and A. Garcia and G. Botella and A. Meyer-Base",

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doi = "10.1117/12.2263554",

language = "English",

isbn = "9781510609341",

series = "Proceedings of SPIE",

publisher = "SPIE-INT SOC OPTICAL ENGINEERING",

booktitle = "SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XIV",

note = "Conference on Smart Biomedical and Physiological Sensor Technology XIV : At SPIE Commercial + Scientific Sensing and Imaging ; Conference date: 09-04-2017 Through 10-04-2017",

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Tahmassebi, A, Pinker-Domenig, K, Wengert, G, Lobbes, M, Stadlbauer, A, Wildburger, NC, Romero, FJ, Morales, DP, Castillo, E, Garcia, A, Botella, G & Meyer-Base, A 2017, The Driving Regulators of the Connectivity Protein Network of Brain Malignancies. in SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XIV., 1021605, SPIE-INT SOC OPTICAL ENGINEERING, Proceedings of SPIE, vol. 10216, Conference on Smart Biomedical and Physiological Sensor Technology XIV, Anaheim, California, United States, 9/04/17. https://doi.org/10.1117/12.2263554

The Driving Regulators of the Connectivity Protein Network of Brain Malignancies. / Tahmassebi, A.; Pinker-Domenig, K.; Wengert, G. et al.
SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XIV. SPIE-INT SOC OPTICAL ENGINEERING, 2017. 1021605 (Proceedings of SPIE, Vol. 10216).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceeding › Academic › peer-review

TY - GEN

T1 - The Driving Regulators of the Connectivity Protein Network of Brain Malignancies

AU - Tahmassebi, A.

AU - Pinker-Domenig, K.

AU - Wengert, G.

AU - Lobbes, M.

AU - Stadlbauer, A.

AU - Wildburger, N.C.

AU - Romero, F.J.

AU - Morales, D.P.

AU - Castillo, E.

AU - Garcia, A.

AU - Botella, G.

AU - Meyer-Base, A.

PY - 2017

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N2 - An important problem in modern therapeutics at the proteomic level remains to identify therapeutic targets in a plentitude of high-throughput data from experiments relevant to a variety of diseases. This paper presents the application of novel modern control concepts, such as pinning controllability and observability applied to the glioma cancer stem cells (GSCs) protein graph network with known and novel association to glioblastoma (GBM). The theoretical frameworks provides us with the minimal number of "driver nodes", which are necessary, and their location to determine the full control over the obtained graph network in order to provide a change in the network's dynamics from an initial state (disease) to a desired state (non-disease). The achieved results will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, to design and test novel therapeutic solutions.

AB - An important problem in modern therapeutics at the proteomic level remains to identify therapeutic targets in a plentitude of high-throughput data from experiments relevant to a variety of diseases. This paper presents the application of novel modern control concepts, such as pinning controllability and observability applied to the glioma cancer stem cells (GSCs) protein graph network with known and novel association to glioblastoma (GBM). The theoretical frameworks provides us with the minimal number of "driver nodes", which are necessary, and their location to determine the full control over the obtained graph network in order to provide a change in the network's dynamics from an initial state (disease) to a desired state (non-disease). The achieved results will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, to design and test novel therapeutic solutions.

KW - Graph theory

KW - nonlinear dynamics

KW - dynamic graph

KW - pathway analysis and control

KW - glioma cancer stem cells

U2 - 10.1117/12.2263554

DO - 10.1117/12.2263554

M3 - Conference article in proceeding

SN - 9781510609341

T3 - Proceedings of SPIE

BT - SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XIV

PB - SPIE-INT SOC OPTICAL ENGINEERING

T2 - Conference on Smart Biomedical and Physiological Sensor Technology XIV

Y2 - 9 April 2017 through 10 April 2017

ER -

The Driving Regulators of the Connectivity Protein Network of Brain Malignancies

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Keywords

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