TY - JOUR
T1 - The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain
AU - Liem, Liong
AU - van Dongen, Eric
AU - Huygen, Frank J.
AU - Staats, Peter
AU - Kramer, Jeff
PY - 2016
Y1 - 2016
N2 - Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:? Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors.? Ablation or modulation of the DRG via continuous thermal radiofrequency and pulsed radiofrequency treatments.? Implanted electrical neurostimulator technologies.? Interventions involving the modification of DRG cellular function at the genetic level by using viral vectors and gene silencing methods.
AB - Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:? Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors.? Ablation or modulation of the DRG via continuous thermal radiofrequency and pulsed radiofrequency treatments.? Implanted electrical neurostimulator technologies.? Interventions involving the modification of DRG cellular function at the genetic level by using viral vectors and gene silencing methods.
U2 - 10.1097/AAP.0000000000000408
DO - 10.1097/AAP.0000000000000408
M3 - Article
C2 - 27224659
SN - 1098-7339
VL - 41
SP - 511
EP - 519
JO - Regional Anesthesia and Pain Medicine
JF - Regional Anesthesia and Pain Medicine
IS - 4
ER -