The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

Liong Liem*, Eric van Dongen, Frank J. Huygen, Peter Staats, Jeff Kramer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Web of Science)

Abstract

Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:? Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors.? Ablation or modulation of the DRG via continuous thermal radiofrequency and pulsed radiofrequency treatments.? Implanted electrical neurostimulator technologies.? Interventions involving the modification of DRG cellular function at the genetic level by using viral vectors and gene silencing methods.
Original languageEnglish
Pages (from-to)511-519
JournalRegional Anesthesia and Pain Medicine
Volume41
Issue number4
DOIs
Publication statusPublished - 2016

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