The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study

M. van Dooren*, E.A.J.D. Lohman, E. Brekelmans, P.A.J. Vissers, J.I. Erdmann, A.E. Braat, J. Hagendoorn, F. Daams, R.M. van Dam, M.T. de Boer, P.B. van den Boezem, B.G. Koerkamp, P.R. de Reuver*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BackgroundDisseminated disease (DD) is often found at (re-)exploration in gallbladder cancer (GBC) patients. We aimed to assess the yield of staging laparoscopy (SL) and identify predictors for DD.MethodsThis retrospective study included patients from all Dutch academic centres with primary GBC (pGBC) and incidentally diagnosed GBC (iGBC) planned for (re-)resection. The yield of SL was determined. In iGBC, predictive factors for DD were assessed.ResultsIn total, 290 patients were included. Of 183 included pGBC patients, 143 underwent laparotomy without SL, and 42 (29%) showed DD perioperatively. SL, conducted in 40 patients, identified DD in eight. DD was found in nine of 32 patients who underwent laparotomy after SL.Of 107 included iGBC patients, 100 underwent laparotomy without SL, and 19 showed DD perioperatively. SL, conducted in seven patients, identified DD in one. Cholecystitis (OR = 4.25; 95% CI 1.51-11.91) and primary R1/R2 resection (OR = 3.94; 95% CI 1.39-11.19) were independent predictive factors for DD.ConclusionsIn pGBC patients, SL may identify DD in up to 20% of patients and should be part of standard management. In iGBC patients, SL is indicated after primary resection for cholecystitis and after initial R1/R2 resection due to the association of these factors with DD.
Original languageEnglish
Article number6
Number of pages8
JournalWorld journal of surgical oncology
Issue number1
Publication statusPublished - 14 Jan 2023


  • Gallbladder neoplasms
  • Gallbladder carcinoma
  • Staging laparoscopy

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