The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study

M. van Dooren; E.A.J.D. Lohman; E. Brekelmans; P.A.J. Vissers; J.I. Erdmann; A.E. Braat; J. Hagendoorn; F. Daams; R.M. van Dam; M.T. de Boer; P.B. van den Boezem; B.G. Koerkamp; P.R. de Reuver

doi:10.1186/s12957-022-02880-z

The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study

M. van Dooren^*, E.A.J.D. Lohman, E. Brekelmans, P.A.J. Vissers, J.I. Erdmann, A.E. Braat, J. Hagendoorn, F. Daams, R.M. van Dam, M.T. de Boer, P.B. van den Boezem, B.G. Koerkamp, P.R. de Reuver^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BackgroundDisseminated disease (DD) is often found at (re-)exploration in gallbladder cancer (GBC) patients. We aimed to assess the yield of staging laparoscopy (SL) and identify predictors for DD.MethodsThis retrospective study included patients from all Dutch academic centres with primary GBC (pGBC) and incidentally diagnosed GBC (iGBC) planned for (re-)resection. The yield of SL was determined. In iGBC, predictive factors for DD were assessed.ResultsIn total, 290 patients were included. Of 183 included pGBC patients, 143 underwent laparotomy without SL, and 42 (29%) showed DD perioperatively. SL, conducted in 40 patients, identified DD in eight. DD was found in nine of 32 patients who underwent laparotomy after SL.Of 107 included iGBC patients, 100 underwent laparotomy without SL, and 19 showed DD perioperatively. SL, conducted in seven patients, identified DD in one. Cholecystitis (OR = 4.25; 95% CI 1.51-11.91) and primary R1/R2 resection (OR = 3.94; 95% CI 1.39-11.19) were independent predictive factors for DD.ConclusionsIn pGBC patients, SL may identify DD in up to 20% of patients and should be part of standard management. In iGBC patients, SL is indicated after primary resection for cholecystitis and after initial R1/R2 resection due to the association of these factors with DD.

Original language	English
Article number	6
Number of pages	8
Journal	World journal of surgical oncology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12957-022-02880-z
Publication status	Published - 14 Jan 2023

Keywords

Gallbladder neoplasms
Gallbladder carcinoma
Staging laparoscopy
MALIGNANCY
CARCINOMA

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10.1186/s12957-022-02880-zLicence: CC BY

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van Dooren, M., Lohman, E. A. J. D., Brekelmans, E., Vissers, P. A. J., Erdmann, J. I., Braat, A. E., Hagendoorn, J., Daams, F., van Dam, R. M., de Boer, M. T., van den Boezem, P. B., Koerkamp, B. G., & de Reuver, P. R. (2023). The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study. World journal of surgical oncology, 21(1), Article 6. https://doi.org/10.1186/s12957-022-02880-z

@article{956c7d9dac714e0eb6d4d1b55d5a14ce,

title = "The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study",

abstract = "BackgroundDisseminated disease (DD) is often found at (re-)exploration in gallbladder cancer (GBC) patients. We aimed to assess the yield of staging laparoscopy (SL) and identify predictors for DD.MethodsThis retrospective study included patients from all Dutch academic centres with primary GBC (pGBC) and incidentally diagnosed GBC (iGBC) planned for (re-)resection. The yield of SL was determined. In iGBC, predictive factors for DD were assessed.ResultsIn total, 290 patients were included. Of 183 included pGBC patients, 143 underwent laparotomy without SL, and 42 (29%) showed DD perioperatively. SL, conducted in 40 patients, identified DD in eight. DD was found in nine of 32 patients who underwent laparotomy after SL.Of 107 included iGBC patients, 100 underwent laparotomy without SL, and 19 showed DD perioperatively. SL, conducted in seven patients, identified DD in one. Cholecystitis (OR = 4.25; 95% CI 1.51-11.91) and primary R1/R2 resection (OR = 3.94; 95% CI 1.39-11.19) were independent predictive factors for DD.ConclusionsIn pGBC patients, SL may identify DD in up to 20% of patients and should be part of standard management. In iGBC patients, SL is indicated after primary resection for cholecystitis and after initial R1/R2 resection due to the association of these factors with DD.",

keywords = "Gallbladder neoplasms, Gallbladder carcinoma, Staging laparoscopy, MALIGNANCY, CARCINOMA",

author = "{van Dooren}, M. and E.A.J.D. Lohman and E. Brekelmans and P.A.J. Vissers and J.I. Erdmann and A.E. Braat and J. Hagendoorn and F. Daams and {van Dam}, R.M. and {de Boer}, M.T. and {van den Boezem}, P.B. and B.G. Koerkamp and {de Reuver}, P.R.",

note = "Funding Information: This research was funded by Foundation ADP. The views expressed in the submitted article are of the authors{\textquoteright} own and not an official position of the institution or funder. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = jan,

day = "14",

doi = "10.1186/s12957-022-02880-z",

language = "English",

volume = "21",

journal = "World journal of surgical oncology",

issn = "1477-7819",

publisher = "BioMed Central",

number = "1",

}

van Dooren, M, Lohman, EAJD, Brekelmans, E, Vissers, PAJ, Erdmann, JI, Braat, AE, Hagendoorn, J, Daams, F, van Dam, RM, de Boer, MT, van den Boezem, PB, Koerkamp, BG & de Reuver, PR 2023, 'The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study', World journal of surgical oncology, vol. 21, no. 1, 6. https://doi.org/10.1186/s12957-022-02880-z

TY - JOUR

T1 - The diagnostic value of staging laparoscopy in gallbladder cancer: a nationwide cohort study

AU - van Dooren, M.

AU - Lohman, E.A.J.D.

AU - Brekelmans, E.

AU - Vissers, P.A.J.

AU - Erdmann, J.I.

AU - Braat, A.E.

AU - Hagendoorn, J.

AU - Daams, F.

AU - van Dam, R.M.

AU - de Boer, M.T.

AU - van den Boezem, P.B.

AU - Koerkamp, B.G.

AU - de Reuver, P.R.

N1 - Funding Information: This research was funded by Foundation ADP. The views expressed in the submitted article are of the authors’ own and not an official position of the institution or funder. Publisher Copyright: © 2023, The Author(s).

PY - 2023/1/14

Y1 - 2023/1/14

N2 - BackgroundDisseminated disease (DD) is often found at (re-)exploration in gallbladder cancer (GBC) patients. We aimed to assess the yield of staging laparoscopy (SL) and identify predictors for DD.MethodsThis retrospective study included patients from all Dutch academic centres with primary GBC (pGBC) and incidentally diagnosed GBC (iGBC) planned for (re-)resection. The yield of SL was determined. In iGBC, predictive factors for DD were assessed.ResultsIn total, 290 patients were included. Of 183 included pGBC patients, 143 underwent laparotomy without SL, and 42 (29%) showed DD perioperatively. SL, conducted in 40 patients, identified DD in eight. DD was found in nine of 32 patients who underwent laparotomy after SL.Of 107 included iGBC patients, 100 underwent laparotomy without SL, and 19 showed DD perioperatively. SL, conducted in seven patients, identified DD in one. Cholecystitis (OR = 4.25; 95% CI 1.51-11.91) and primary R1/R2 resection (OR = 3.94; 95% CI 1.39-11.19) were independent predictive factors for DD.ConclusionsIn pGBC patients, SL may identify DD in up to 20% of patients and should be part of standard management. In iGBC patients, SL is indicated after primary resection for cholecystitis and after initial R1/R2 resection due to the association of these factors with DD.

AB - BackgroundDisseminated disease (DD) is often found at (re-)exploration in gallbladder cancer (GBC) patients. We aimed to assess the yield of staging laparoscopy (SL) and identify predictors for DD.MethodsThis retrospective study included patients from all Dutch academic centres with primary GBC (pGBC) and incidentally diagnosed GBC (iGBC) planned for (re-)resection. The yield of SL was determined. In iGBC, predictive factors for DD were assessed.ResultsIn total, 290 patients were included. Of 183 included pGBC patients, 143 underwent laparotomy without SL, and 42 (29%) showed DD perioperatively. SL, conducted in 40 patients, identified DD in eight. DD was found in nine of 32 patients who underwent laparotomy after SL.Of 107 included iGBC patients, 100 underwent laparotomy without SL, and 19 showed DD perioperatively. SL, conducted in seven patients, identified DD in one. Cholecystitis (OR = 4.25; 95% CI 1.51-11.91) and primary R1/R2 resection (OR = 3.94; 95% CI 1.39-11.19) were independent predictive factors for DD.ConclusionsIn pGBC patients, SL may identify DD in up to 20% of patients and should be part of standard management. In iGBC patients, SL is indicated after primary resection for cholecystitis and after initial R1/R2 resection due to the association of these factors with DD.

KW - Gallbladder neoplasms

KW - Gallbladder carcinoma

KW - Staging laparoscopy

KW - MALIGNANCY

KW - CARCINOMA

U2 - 10.1186/s12957-022-02880-z

DO - 10.1186/s12957-022-02880-z

M3 - Article

C2 - 36641472

SN - 1477-7819

VL - 21

JO - World journal of surgical oncology

JF - World journal of surgical oncology

IS - 1

M1 - 6

ER -