The Diabetes Pearl: Diabetes biobanking in The Netherlands

Esther Van't Riet; Miranda T. Schram; Evertine J. Abbink; Wanda M. Admiraal; Marja W. Dijk-Schaap; Frits Holleman; Giel Nijpels; Behiye Ozcan; Hanno Pijl; Nicolaas C. Schaper; Eric J. G. Sijbrands; Bianca Silvius; Cees J. Tack; Harold W. de Valk; Bruce H. R. Wolffenbuttel; Coen D. A. Stehouwer; Jacqueline M. Dekker

doi:10.1186/1471-2458-12-949

The Diabetes Pearl: Diabetes biobanking in The Netherlands

Esther Van't Riet^*
, Miranda T. Schram
, Evertine J. Abbink
, Wanda M. Admiraal
, Marja W. Dijk-Schaap
, Frits Holleman
, Giel Nijpels
, Behiye Ozcan
, Hanno Pijl
, Nicolaas C. Schaper
, Eric J. G. Sijbrands
, Bianca Silvius
, Cees J. Tack
, Harold W. de Valk
, Bruce H. R. Wolffenbuttel
, Coen D. A. Stehouwer
, Jacqueline M. Dekker

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Type 2 diabetes is associated with considerable comorbidity and severe complications, which reduce quality of life of the patients and require high levels of healthcare. The Diabetes Pearl is a large cohort of patients diagnosed with type 2 diabetes, covering different geographical areas in the Netherlands. The aim of the study is to create a research infrastructure that will allow the study of risk factors, including biomarkers and genetic determinants for severe diabetes complications. Methods/design: Baseline examinations began November 2009 and will continue through 2012. By the end of 2012, it is expected that 7000 patients with type 2 diabetes will be included in the Diabetes Pearl cohort. To ensure quality of the data collected, standard operation procedures were developed and used in all 8 recruitment centers. From all patients who provide informed consent, the following information is collected: personal information, medication use, physical examination (antropometry, blood pressure, electrocardiography (ECG), retina photographs, ankle-brachial index, peripheral vibration perception), self-report questionnaire (socio-economic status, lifestyle, (family) history of disease, and psychosocial well-being), laboratory measurements (glucose, A1c, lipid profile, kidney function), biobank material (storage of urine and blood samples and isolated DNA). All gathered clinical data and biobank information is uploaded to a database for storage on a national level. Biobanks are maintained locally at all recruitment centers. Discussion: The Diabetes Pearl is large-scale cohort of type 2 diabetes patients in the Netherlands aiming to study risk factors, including biomarkers and genetic markers, for disease deterioration and the development of severe diabetes complications. As a result of the well-designed research design and the national coverage, the Diabetes Pearl data can be of great value to national and international researchers with an interest in diabetes related research.

Original language	English
Pages (from-to)	949
Journal	BMC Public Health
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1471-2458-12-949
Publication status	Published - 6 Nov 2012

Keywords

Design
Biobank
Research infrastructure
Type 2 diabetes
The Netherlands

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10.1186/1471-2458-12-949Licence: CC BY

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Van't Riet, E., Schram, M. T., Abbink, E. J., Admiraal, W. M., Dijk-Schaap, M. W., Holleman, F., Nijpels, G., Ozcan, B., Pijl, H., Schaper, N. C., Sijbrands, E. J. G., Silvius, B., Tack, C. J., de Valk, H. W., Wolffenbuttel, B. H. R., Stehouwer, C. D. A., & Dekker, J. M. (2012). The Diabetes Pearl: Diabetes biobanking in The Netherlands. BMC Public Health, 12(1), 949. https://doi.org/10.1186/1471-2458-12-949

@article{e72cc1ff7c0044cea8c6a6d3647839b4,

title = "The Diabetes Pearl: Diabetes biobanking in The Netherlands",

abstract = "Background: Type 2 diabetes is associated with considerable comorbidity and severe complications, which reduce quality of life of the patients and require high levels of healthcare. The Diabetes Pearl is a large cohort of patients diagnosed with type 2 diabetes, covering different geographical areas in the Netherlands. The aim of the study is to create a research infrastructure that will allow the study of risk factors, including biomarkers and genetic determinants for severe diabetes complications. Methods/design: Baseline examinations began November 2009 and will continue through 2012. By the end of 2012, it is expected that 7000 patients with type 2 diabetes will be included in the Diabetes Pearl cohort. To ensure quality of the data collected, standard operation procedures were developed and used in all 8 recruitment centers. From all patients who provide informed consent, the following information is collected: personal information, medication use, physical examination (antropometry, blood pressure, electrocardiography (ECG), retina photographs, ankle-brachial index, peripheral vibration perception), self-report questionnaire (socio-economic status, lifestyle, (family) history of disease, and psychosocial well-being), laboratory measurements (glucose, A1c, lipid profile, kidney function), biobank material (storage of urine and blood samples and isolated DNA). All gathered clinical data and biobank information is uploaded to a database for storage on a national level. Biobanks are maintained locally at all recruitment centers. Discussion: The Diabetes Pearl is large-scale cohort of type 2 diabetes patients in the Netherlands aiming to study risk factors, including biomarkers and genetic markers, for disease deterioration and the development of severe diabetes complications. As a result of the well-designed research design and the national coverage, the Diabetes Pearl data can be of great value to national and international researchers with an interest in diabetes related research.",

keywords = "Design, Biobank, Research infrastructure, Type 2 diabetes, The Netherlands",

author = "\{Van't Riet\}, Esther and Schram, \{Miranda T.\} and Abbink, \{Evertine J.\} and Admiraal, \{Wanda M.\} and Dijk-Schaap, \{Marja W.\} and Frits Holleman and Giel Nijpels and Behiye Ozcan and Hanno Pijl and Schaper, \{Nicolaas C.\} and Sijbrands, \{Eric J. G.\} and Bianca Silvius and Tack, \{Cees J.\} and \{de Valk\}, \{Harold W.\} and Wolffenbuttel, \{Bruce H. R.\} and Stehouwer, \{Coen D. A.\} and Dekker, \{Jacqueline M.\}",

year = "2012",

month = nov,

day = "6",

doi = "10.1186/1471-2458-12-949",

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Van't Riet, E, Schram, MT, Abbink, EJ, Admiraal, WM, Dijk-Schaap, MW, Holleman, F, Nijpels, G, Ozcan, B, Pijl, H, Schaper, NC, Sijbrands, EJG, Silvius, B, Tack, CJ, de Valk, HW, Wolffenbuttel, BHR, Stehouwer, CDA & Dekker, JM 2012, 'The Diabetes Pearl: Diabetes biobanking in The Netherlands', BMC Public Health, vol. 12, no. 1, pp. 949. https://doi.org/10.1186/1471-2458-12-949

TY - JOUR

T1 - The Diabetes Pearl: Diabetes biobanking in The Netherlands

AU - Van't Riet, Esther

AU - Schram, Miranda T.

AU - Abbink, Evertine J.

AU - Admiraal, Wanda M.

AU - Dijk-Schaap, Marja W.

AU - Holleman, Frits

AU - Nijpels, Giel

AU - Ozcan, Behiye

AU - Pijl, Hanno

AU - Schaper, Nicolaas C.

AU - Sijbrands, Eric J. G.

AU - Silvius, Bianca

AU - Tack, Cees J.

AU - de Valk, Harold W.

AU - Wolffenbuttel, Bruce H. R.

AU - Stehouwer, Coen D. A.

AU - Dekker, Jacqueline M.

PY - 2012/11/6

Y1 - 2012/11/6

N2 - Background: Type 2 diabetes is associated with considerable comorbidity and severe complications, which reduce quality of life of the patients and require high levels of healthcare. The Diabetes Pearl is a large cohort of patients diagnosed with type 2 diabetes, covering different geographical areas in the Netherlands. The aim of the study is to create a research infrastructure that will allow the study of risk factors, including biomarkers and genetic determinants for severe diabetes complications. Methods/design: Baseline examinations began November 2009 and will continue through 2012. By the end of 2012, it is expected that 7000 patients with type 2 diabetes will be included in the Diabetes Pearl cohort. To ensure quality of the data collected, standard operation procedures were developed and used in all 8 recruitment centers. From all patients who provide informed consent, the following information is collected: personal information, medication use, physical examination (antropometry, blood pressure, electrocardiography (ECG), retina photographs, ankle-brachial index, peripheral vibration perception), self-report questionnaire (socio-economic status, lifestyle, (family) history of disease, and psychosocial well-being), laboratory measurements (glucose, A1c, lipid profile, kidney function), biobank material (storage of urine and blood samples and isolated DNA). All gathered clinical data and biobank information is uploaded to a database for storage on a national level. Biobanks are maintained locally at all recruitment centers. Discussion: The Diabetes Pearl is large-scale cohort of type 2 diabetes patients in the Netherlands aiming to study risk factors, including biomarkers and genetic markers, for disease deterioration and the development of severe diabetes complications. As a result of the well-designed research design and the national coverage, the Diabetes Pearl data can be of great value to national and international researchers with an interest in diabetes related research.

AB - Background: Type 2 diabetes is associated with considerable comorbidity and severe complications, which reduce quality of life of the patients and require high levels of healthcare. The Diabetes Pearl is a large cohort of patients diagnosed with type 2 diabetes, covering different geographical areas in the Netherlands. The aim of the study is to create a research infrastructure that will allow the study of risk factors, including biomarkers and genetic determinants for severe diabetes complications. Methods/design: Baseline examinations began November 2009 and will continue through 2012. By the end of 2012, it is expected that 7000 patients with type 2 diabetes will be included in the Diabetes Pearl cohort. To ensure quality of the data collected, standard operation procedures were developed and used in all 8 recruitment centers. From all patients who provide informed consent, the following information is collected: personal information, medication use, physical examination (antropometry, blood pressure, electrocardiography (ECG), retina photographs, ankle-brachial index, peripheral vibration perception), self-report questionnaire (socio-economic status, lifestyle, (family) history of disease, and psychosocial well-being), laboratory measurements (glucose, A1c, lipid profile, kidney function), biobank material (storage of urine and blood samples and isolated DNA). All gathered clinical data and biobank information is uploaded to a database for storage on a national level. Biobanks are maintained locally at all recruitment centers. Discussion: The Diabetes Pearl is large-scale cohort of type 2 diabetes patients in the Netherlands aiming to study risk factors, including biomarkers and genetic markers, for disease deterioration and the development of severe diabetes complications. As a result of the well-designed research design and the national coverage, the Diabetes Pearl data can be of great value to national and international researchers with an interest in diabetes related research.

KW - Design

KW - Biobank

KW - Research infrastructure

KW - Type 2 diabetes

KW - The Netherlands

U2 - 10.1186/1471-2458-12-949

DO - 10.1186/1471-2458-12-949

M3 - Article

C2 - 23130988

SN - 1471-2458

VL - 12

SP - 949

JO - BMC Public Health

JF - BMC Public Health

IS - 1

ER -

The Diabetes Pearl: Diabetes biobanking in The Netherlands

Abstract

Keywords

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