@inbook{cf493b1f9ec74284a22f348856fc91d9,
title = "The Development of the Gut Microbiota in Childhood and Its Distortion by Lifestyle Changes",
abstract = "The gut microbiota is established in the newborn period and plays a pivotal role in the development of the mucosal tissue, immune maturation, and host metabolism. Distortions in the assembly and maturation of the microbiota during this critical time-window can therefore have profound effects on future health and the susceptibility to non-communicable diseases. In this chapter, we provide an overview of the ecological processes involved in the establishment of the indigenous microbial communities during infancy and childhood. Moreover, we summarize the current knowledge on the disruptive effects of lifestyle changes on gut microbiota assembly and maturation. Finally, we highlight important areas for further research in order to identify approaches to revert the deprivation of our microbiota.",
keywords = "Antibiotics, Birth mode, Breastfeeding, Complementary food, Ecological theory, Microbiota assembly, Natural environment, Social interactions",
author = "John Penders and {van Best}, Niels",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
month = jan,
day = "1",
doi = "10.1007/978-3-030-91051-8_7",
language = "English",
volume = "89",
series = "Progress in Inflammation Research",
publisher = "Springer Nature Switzerland AG",
pages = "197--219",
booktitle = "Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis",
address = "Switzerland",
}