The Current Role of Whole Brain Radiation Therapy in Non–Small Cell Lung Cancer Patients

Gokoulakrichenane Loganadane; Lizza Hendriks; Cecile Le Pechoux; Antonin Levy

doi:10.1016/j.jtho.2017.07.006

The Current Role of Whole Brain Radiation Therapy in Non–Small Cell Lung Cancer Patients

Gokoulakrichenane Loganadane, Lizza Hendriks, Cecile Le Pechoux, Antonin Levy^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

The incidence of brain metastases has increased in patients with NSCLC as a result of better systemic disease control and advances in imaging modalities. Whole brain radiotherapy (WBRT) has been the mainstay treatment of multiple symptomatic brain metastases for years. A number of recent publications have questioned its place in the absence of a survival and quality of life benefit and the possible risk for long-term neurotoxicity. Omission or deferral of WBRT and strategies consisting of stereotactic radiosurgery or delivery of systemic therapies alone are being proposed more and more. However, critical analysis of the literature shows that WBRT still has relevant indications in well-selected patients. Within this review, we discuss the place of WBRT in the modern management of patients with NSCLC. (C) 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1467-1477
Number of pages	11
Journal	Journal of Thoracic Oncology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/j.jtho.2017.07.006
Publication status	Published - Oct 2017

Keywords

Radiotherapy
Stereotactic radiotherapy
Brain irradiation
Targeted therapy
EGFR mutation
ALK translocation
PROPHYLACTIC CRANIAL IRRADIATION
RANDOMIZED CONTROLLED-TRIAL
PHASE-III TRIAL
QUALITY-OF-LIFE
STEREOTACTIC RADIOSURGERY
OPEN-LABEL
CEREBRAL METASTASES
SINGLE METASTASES
CLINICAL-TRIAL
RADIOTHERAPY

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10.1016/j.jtho.2017.07.006

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Cite this

@article{a9b78bfcdc6c4ce7999183e342bd8691,

title = "The Current Role of Whole Brain Radiation Therapy in Non–Small Cell Lung Cancer Patients",

abstract = "The incidence of brain metastases has increased in patients with NSCLC as a result of better systemic disease control and advances in imaging modalities. Whole brain radiotherapy (WBRT) has been the mainstay treatment of multiple symptomatic brain metastases for years. A number of recent publications have questioned its place in the absence of a survival and quality of life benefit and the possible risk for long-term neurotoxicity. Omission or deferral of WBRT and strategies consisting of stereotactic radiosurgery or delivery of systemic therapies alone are being proposed more and more. However, critical analysis of the literature shows that WBRT still has relevant indications in well-selected patients. Within this review, we discuss the place of WBRT in the modern management of patients with NSCLC. (C) 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.",

keywords = "Radiotherapy, Stereotactic radiotherapy, Brain irradiation, Targeted therapy, EGFR mutation, ALK translocation, PROPHYLACTIC CRANIAL IRRADIATION, RANDOMIZED CONTROLLED-TRIAL, PHASE-III TRIAL, QUALITY-OF-LIFE, STEREOTACTIC RADIOSURGERY, OPEN-LABEL, CEREBRAL METASTASES, SINGLE METASTASES, CLINICAL-TRIAL, RADIOTHERAPY",

author = "Gokoulakrichenane Loganadane and Lizza Hendriks and {Le Pechoux}, Cecile and Antonin Levy",

year = "2017",

month = oct,

doi = "10.1016/j.jtho.2017.07.006",

language = "English",

volume = "12",

pages = "1467--1477",

journal = "Journal of Thoracic Oncology",

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T1 - The Current Role of Whole Brain Radiation Therapy in Non–Small Cell Lung Cancer Patients

AU - Loganadane, Gokoulakrichenane

AU - Hendriks, Lizza

AU - Le Pechoux, Cecile

AU - Levy, Antonin

PY - 2017/10

Y1 - 2017/10

N2 - The incidence of brain metastases has increased in patients with NSCLC as a result of better systemic disease control and advances in imaging modalities. Whole brain radiotherapy (WBRT) has been the mainstay treatment of multiple symptomatic brain metastases for years. A number of recent publications have questioned its place in the absence of a survival and quality of life benefit and the possible risk for long-term neurotoxicity. Omission or deferral of WBRT and strategies consisting of stereotactic radiosurgery or delivery of systemic therapies alone are being proposed more and more. However, critical analysis of the literature shows that WBRT still has relevant indications in well-selected patients. Within this review, we discuss the place of WBRT in the modern management of patients with NSCLC. (C) 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

AB - The incidence of brain metastases has increased in patients with NSCLC as a result of better systemic disease control and advances in imaging modalities. Whole brain radiotherapy (WBRT) has been the mainstay treatment of multiple symptomatic brain metastases for years. A number of recent publications have questioned its place in the absence of a survival and quality of life benefit and the possible risk for long-term neurotoxicity. Omission or deferral of WBRT and strategies consisting of stereotactic radiosurgery or delivery of systemic therapies alone are being proposed more and more. However, critical analysis of the literature shows that WBRT still has relevant indications in well-selected patients. Within this review, we discuss the place of WBRT in the modern management of patients with NSCLC. (C) 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

KW - Radiotherapy

KW - Stereotactic radiotherapy

KW - Brain irradiation

KW - Targeted therapy

KW - EGFR mutation

KW - ALK translocation

KW - PROPHYLACTIC CRANIAL IRRADIATION

KW - RANDOMIZED CONTROLLED-TRIAL

KW - PHASE-III TRIAL

KW - QUALITY-OF-LIFE

KW - STEREOTACTIC RADIOSURGERY

KW - OPEN-LABEL

KW - CEREBRAL METASTASES

KW - SINGLE METASTASES

KW - CLINICAL-TRIAL

KW - RADIOTHERAPY

U2 - 10.1016/j.jtho.2017.07.006

DO - 10.1016/j.jtho.2017.07.006

M3 - (Systematic) Review article

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VL - 12

SP - 1467

EP - 1477

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 10

ER -