TY - JOUR
T1 - The cross-sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study).
AU - van Greevenbroek, M.M.J.
AU - Jacobs, M.
AU - van der Kallen, C.J.H.
AU - Vermeulen, V.M.
AU - Jansen, E.H.
AU - Schalkwijk, C.G.
AU - Ferreira, I.
AU - Feskens, E.J.
AU - Stehouwer, C.D.A.
PY - 2011/4
Y1 - 2011/4
N2 - Eur J Clin Invest 2010 ABSTRACT: Background Complement C3, a central component of the innate immune system is increased in subjects with obesity and type 2 diabetes and is a novel risk factor for cardiovascular disease. We hypothesized that the strong association between insulin resistance and circulating amounts of C3 may be related to hepatic fat accumulation -independent of central obesity itself and of a general low-grade inflammatory response. Research question To what extent is the association between insulin resistance and C3 explained by plasma levels of alanine aminotransferase (ALT) as a surrogate of hepatic fat accumulation. Methods Cross-sectional analyses conducted in the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. Analyses were restricted to subjects with none-to-moderate alcohol consumption (n = 453, 61.4% men). Multiple linear regression analyses were used to investigate the association between HOMA2IR (main determinant) and circulating complement C3 (main outcome), and the mediating role of ALT herein. All analyses were adjusted for age, sex, presence of type 2 diabetes mellitus or heart disease, use of medication, smoking, alcohol consumption, waist circumference and inflammation. Results Insulin resistance (estimated as HOMA2IR) was strongly associated with circulating C3 (standardized regression coefficient beta 0.40 [95% CI: 0.30; 0.49]) and also with ALT (beta 0.44 [0.34; 0.54]), both adjusted for the above-mentioned covariates. The association between HOMA2IR and C3 was attenuated after further adjustment for ALT (beta decreased to 0.34 [0.24; 0.44]). Concluding Remarks Plasma ALT can explain 14.2% of the strong association between insulin resistance and circulating concentrations of complement C3, independent of central obesity and general inflammation.
AB - Eur J Clin Invest 2010 ABSTRACT: Background Complement C3, a central component of the innate immune system is increased in subjects with obesity and type 2 diabetes and is a novel risk factor for cardiovascular disease. We hypothesized that the strong association between insulin resistance and circulating amounts of C3 may be related to hepatic fat accumulation -independent of central obesity itself and of a general low-grade inflammatory response. Research question To what extent is the association between insulin resistance and C3 explained by plasma levels of alanine aminotransferase (ALT) as a surrogate of hepatic fat accumulation. Methods Cross-sectional analyses conducted in the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. Analyses were restricted to subjects with none-to-moderate alcohol consumption (n = 453, 61.4% men). Multiple linear regression analyses were used to investigate the association between HOMA2IR (main determinant) and circulating complement C3 (main outcome), and the mediating role of ALT herein. All analyses were adjusted for age, sex, presence of type 2 diabetes mellitus or heart disease, use of medication, smoking, alcohol consumption, waist circumference and inflammation. Results Insulin resistance (estimated as HOMA2IR) was strongly associated with circulating C3 (standardized regression coefficient beta 0.40 [95% CI: 0.30; 0.49]) and also with ALT (beta 0.44 [0.34; 0.54]), both adjusted for the above-mentioned covariates. The association between HOMA2IR and C3 was attenuated after further adjustment for ALT (beta decreased to 0.34 [0.24; 0.44]). Concluding Remarks Plasma ALT can explain 14.2% of the strong association between insulin resistance and circulating concentrations of complement C3, independent of central obesity and general inflammation.
KW - Alanine aminotransferase
KW - complement C3
KW - insulin resistance
KW - FATTY LIVER-DISEASE
KW - POPULATION-BASED COHORT
KW - MYOCARDIAL-INFARCTION
KW - METABOLIC SYNDROME
KW - RISK-FACTOR
KW - SERUM C3
KW - NONALCOHOLIC STEATOHEPATITIS
KW - ENDOTHELIAL-CELLS
KW - REACTIVE PROTEIN
KW - COMPONENT-3
U2 - 10.1111/j.1365-2362.2010.02418.x
DO - 10.1111/j.1365-2362.2010.02418.x
M3 - Article
SN - 0014-2972
VL - 41
SP - 372
EP - 379
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
IS - 4
ER -