The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients

Laura C J Sijben; Werner H Mess; Uwe Walter; A Miranda L Janssen; Mark L Kuijf; Mayke Oosterloo; Wim E J Weber; Marcus L F Janssen

doi:10.1016/j.ensci.2022.100400

The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients

Laura C J Sijben^*, Werner H Mess, Uwe Walter, A Miranda L Janssen, Mark L Kuijf, Mayke Oosterloo, Wim E J Weber, Marcus L F Janssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control participants.

Methods: In this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound.

Results: The mean CSA of the left vagus nerve in the PD and the control group was respectively 2.10 and 1.90 and of the right respectively 2.54 and 2.24 mm2. There is no difference in CSA of the vagus nerve in PD patients compared to controls (p = .079). The mean CSA of the right vagus nerve was significantly larger than the left (p < .001). Age, sex and autonomic symptoms were no significant predictors of the CSA of the vagus nerve.

Conclusion: These findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD.

Original language	English
Article number	100400
Journal	eNeurologicalSci
Volume	27
DOIs	https://doi.org/10.1016/j.ensci.2022.100400
Publication status	Published - Jun 2022

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Cite this

@article{22292b8eed7545759616818612c5be55,

title = "The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients",

abstract = "Background: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control participants.Methods: In this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound.Results: The mean CSA of the left vagus nerve in the PD and the control group was respectively 2.10 and 1.90 and of the right respectively 2.54 and 2.24 mm2. There is no difference in CSA of the vagus nerve in PD patients compared to controls (p = .079). The mean CSA of the right vagus nerve was significantly larger than the left (p < .001). Age, sex and autonomic symptoms were no significant predictors of the CSA of the vagus nerve.Conclusion: These findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD.",

author = "Sijben, {Laura C J} and Mess, {Werner H} and Uwe Walter and Janssen, {A Miranda L} and {L Kuijf}, Mark and Mayke Oosterloo and Weber, {Wim E J} and Janssen, {Marcus L F}",

note = "{\textcopyright} 2022 The Authors. Published by Elsevier B.V.",

year = "2022",

month = jun,

doi = "10.1016/j.ensci.2022.100400",

language = "English",

volume = "27",

journal = "eNeurologicalSci",

issn = "2405-6502",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - The cross-sectional area of the vagus nerve is not reduced in Parkinson's disease patients

AU - Sijben, Laura C J

AU - Mess, Werner H

AU - Walter, Uwe

AU - Janssen, A Miranda L

AU - L Kuijf, Mark

AU - Oosterloo, Mayke

AU - Weber, Wim E J

AU - Janssen, Marcus L F

PY - 2022/6

Y1 - 2022/6

N2 - Background: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control participants.Methods: In this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound.Results: The mean CSA of the left vagus nerve in the PD and the control group was respectively 2.10 and 1.90 and of the right respectively 2.54 and 2.24 mm2. There is no difference in CSA of the vagus nerve in PD patients compared to controls (p = .079). The mean CSA of the right vagus nerve was significantly larger than the left (p < .001). Age, sex and autonomic symptoms were no significant predictors of the CSA of the vagus nerve.Conclusion: These findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD.

AB - Background: Recent studies have revealed the importance of the gut brain axis in the development of Parkinson's disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control participants.Methods: In this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound.Results: The mean CSA of the left vagus nerve in the PD and the control group was respectively 2.10 and 1.90 and of the right respectively 2.54 and 2.24 mm2. There is no difference in CSA of the vagus nerve in PD patients compared to controls (p = .079). The mean CSA of the right vagus nerve was significantly larger than the left (p < .001). Age, sex and autonomic symptoms were no significant predictors of the CSA of the vagus nerve.Conclusion: These findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD.

U2 - 10.1016/j.ensci.2022.100400

DO - 10.1016/j.ensci.2022.100400

M3 - Article

C2 - 35592106

SN - 2405-6502

VL - 27

JO - eNeurologicalSci

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