The COVID-19 pandemic accelerates and exacerbates many preexisting tendencies in the global political economy. Consequently, the crisis of the liberal international order (LIO), which has been ongoing for several years, is also being affected by the pandemic. These effects are, however, not uniform: some aspects of the crisis of the LIO, as a multidimensional phenomenon, are under more pressure than others. In this article, I detail these varied effects with a specific focus on questions of geopolitics and hegemonic change. I argue that especially the societal level, where socioeconomic distortions and popular discontent are long-existing drivers of crisis, will be severely hit by the social and economic fallout of the pandemic. I conclude by suggesting a set of hypotheses regarding the effects of the COVID-19 pandemic on the crisis of the LIO that can be tested once more data becomes available.