The complement system in glioblastoma multiforme

T. A. M. Bouwens van der Vlis; J. M. Kros; D. A. M. Mustafa; R. T. A. van Wijck; L. Ackermans; P. M. van Hagen; P. J. van der Spek

doi:10.1186/s40478-018-0591-4

The complement system in glioblastoma multiforme

T. A. M. Bouwens van der Vlis, J. M. Kros^*, D. A. M. Mustafa, R. T. A. van Wijck, L. Ackermans, P. M. van Hagen, P. J. van der Spek

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.

Original language	English
Article number	91
Number of pages	12
Journal	Acta neuropathologica communications
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/s40478-018-0591-4
Publication status	Published - 12 Sept 2018

Keywords

PIGMENT EPITHELIAL-CELLS
REGULATORY T-CELLS
CANCER STEM-CELLS
ENDOTHELIAL-CELLS
TUMOR MICROENVIRONMENT
GLIOMA-CELLS
BRAIN-TUMORS
PERIVASCULAR NICHE
ANAPHYLATOXIN C5A
GENE-EXPRESSION

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https://doi.org/10.1186/s40478-018-0591-4

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title = "The complement system in glioblastoma multiforme",

abstract = "The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.",

keywords = "PIGMENT EPITHELIAL-CELLS, REGULATORY T-CELLS, CANCER STEM-CELLS, ENDOTHELIAL-CELLS, TUMOR MICROENVIRONMENT, GLIOMA-CELLS, BRAIN-TUMORS, PERIVASCULAR NICHE, ANAPHYLATOXIN C5A, GENE-EXPRESSION",

author = "{van der Vlis}, {T. A. M. Bouwens} and Kros, {J. M.} and Mustafa, {D. A. M.} and {van Wijck}, {R. T. A.} and L. Ackermans and {van Hagen}, {P. M.} and {van der Spek}, {P. J.}",

year = "2018",

month = sep,

day = "12",

doi = "10.1186/s40478-018-0591-4",

language = "English",

volume = "6",

journal = "Acta neuropathologica communications",

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AU - van der Vlis, T. A. M. Bouwens

AU - Kros, J. M.

AU - Mustafa, D. A. M.

AU - van Wijck, R. T. A.

AU - Ackermans, L.

AU - van Hagen, P. M.

AU - van der Spek, P. J.

PY - 2018/9/12

Y1 - 2018/9/12

N2 - The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.

AB - The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.

KW - PIGMENT EPITHELIAL-CELLS

KW - REGULATORY T-CELLS

KW - CANCER STEM-CELLS

KW - ENDOTHELIAL-CELLS

KW - TUMOR MICROENVIRONMENT

KW - GLIOMA-CELLS

KW - BRAIN-TUMORS

KW - PERIVASCULAR NICHE

KW - ANAPHYLATOXIN C5A

KW - GENE-EXPRESSION

U2 - 10.1186/s40478-018-0591-4

DO - 10.1186/s40478-018-0591-4

M3 - (Systematic) Review article

C2 - 30208949

SN - 2051-5960

VL - 6

JO - Acta neuropathologica communications

JF - Acta neuropathologica communications

IS - 1

M1 - 91

ER -

The complement system in glioblastoma multiforme

Abstract

Keywords

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