The Combined Effects of Amyloidosis and Serotonin Deficiency by Tryptophan Hydroxylase-2 Knockout Impacts Viability of the APP/PS1 Mouse Model of Alzheimer's Disease

Christian Ulrich von Linstow, Jonas Waider, Marianne Skov-Skov Bergh, Marco Anzalone, Cecilie Madsen, Aina Battle Nicolau, Martin Wirenfeldt, Klaus-Peter Lesch, Bente Finsen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1283-1300
Number of pages18
JournalJournal of Alzheimer's Disease
Volume85
Issue number3
Early online date16 Dec 2021
DOIs
Publication statusPublished - 2022

Keywords

  • 5-HT
  • 5-HT4 RECEPTOR
  • A beta PP processing
  • APP/PS1
  • Alzheimer's disease
  • BETA LEVELS
  • DEMENTIA
  • DEPLETION
  • FLUID
  • METABOLISM
  • MICE
  • MICROGLIA
  • NEURONS
  • PATHOLOGY
  • cerebral amyloidosis
  • cerebrospinal fluid
  • neuroinflammation
  • tryptophan hydroxylase 2

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