The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

M. Solmi*, A. Estrade, T. Thompson, A. Agorastos, J. Radua, S. Cortese, E. Dragioti, F. Leisch, D. Vancampfort, L.C. Thygesen, H. Aschauer, M. Schloegelhofer, E. Akimova, A. Schneeberger, C.G. Huber, G. Hasler, P. Conus, K.Q. Do Cuenod, R. von Kanel, G. ArrondoP. Fusar-Poli, P. Gorwood, P.M. Llorca, M.O. Krebs, E. Scanferla, T. Kishimoto, G. Rabbani, K. Skonieczna-Zydecka, P. Brambilla, A. Favaro, A. Takamiya, L. Zoccante, M. Colizzi, J. Bourgin, K. Kaminski, M. Moghadasin, S. Seedat, E. Matthews, J. Wells, E. Vassilopoulou, A. Gadelha, K.P. Su, J.S. Kwon, M. Kim, T.Y. Lee, O. Papsuev, D. Mankova, A. Boscutti, C. Gerunda, D. Saccon, T. van Amelsvoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: . High-quality comprehensive data on short-/long-term physical/mental health effects of the COVID-19 pandemic are needed.Methods: . The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is an international, multi-language (n=30) project involving >230 investigators from 49 countries/territories/regions, endorsed by national/international professional associations. COH-FIT is a multi-wave, on-line anonymous, cross-sectional survey [wave 1: 04/2020 until the end of the pandemic, 12 months waves 2/3 starting 6/24 months threreafter] for adults, adolescents (14-17), and children (6-13), utilizing non-probability/snowball and representative sampling. COH-FIT aims to identify non-modifiable/modifiable risk factors/treatment targets to inform prevention/intervention programs to improve social/health outcomes in the general population/vulnerable subgrous during/after COVID-19. In adults, co-primary outcomes are change from pre-COVID-19 to intra-COVID-19 in well-being (WHO-5) and a composite psychopathology P-Score. Key secondary outcomes are a P-extended score, global mental and physical health. Secondary outcomes include health-service utilization/ functioning, treatment adherence, functioning, symptoms/behaviors/emotions, substance use, violence, among others.Results: . Starting 04/26/2020, up to 14/07/2021 >151,000 people from 155 countries/territories/regions and six continents have participated. Representative samples of >= 1,000 adults have been collected in 15 countries. Overall, 43.0% had prior physical disorders, 16.3% had prior mental disorders, 26.5% were health care workers, 8.2% were aged >= 65 years, 19.3% were exposed to someone infected with COVID-19, 76.1% had been in quarantine, and 2.1% had been COVID 19-positive.Limitations: . Cross-sectional survey, preponderance of non-representative participants.Conclusions: . Results from COH-FIT will comprehensively quantify the impact of COVID-19, seeking to identify high-risk groups in need for acute and long-term intervention, and inform evidence-based health policies/strategies during this/future pandemics.
Original languageEnglish
Pages (from-to)393-407
Number of pages15
JournalJournal of Affective Disorders
Publication statusPublished - 15 Feb 2022


  • COVID-19
  • mental health
  • functioning
  • physical health
  • representative
  • well-being
  • resilience
  • survey
  • international
  • psychiatry
  • depression
  • anxiety
  • post-traumatic
  • children
  • adolescents
  • adults
  • CARE

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