The cocoa flavanol (-)-epicatechin protects the cortisol response.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Various health benefits of the cocoa flavanol (-)-epicatechin (EC) have been attributed to its antioxidant and anti-inflammatory potency. In the present study we investigated whether EC is able to prevent deterioration of the anti-inflammatory effect of the glucocorticoid (GC) cortisol in the presence of oxidative stress. It was found that cortisol reduces inflammation in differentiated monocytes. Oxidative stress extinguishes the anti-inflammatory effect of cortisol, leading to cortisol resistance. EC reduces intracellular oxidative stress as well as the development of cortisol resistance. This further deciphers the enigmatic mechanism of EC by which it exerts its anti-inflammatory and antioxidant action. The observed effect of the cocoa flavanol EC will especially be of relevance in pathophysiological conditions with increased oxidative stress and consequential GC resistance and provides a fundament for the rational use of dietary antioxidants.
Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalPharmacological Research
Volume79
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Glucocorticoid resistance
  • Cortisol
  • (-)-Epicatechin
  • Anti-oxidant
  • Inflammation
  • Monocytes
  • OBSTRUCTIVE PULMONARY-DISEASE
  • OXIDATIVE STRESS
  • CORTICOSTEROID RESISTANCE
  • N-ACETYLCYSTEINE
  • CARDIOVASCULAR-DISEASE
  • ANTIOXIDANT PROPERTIES
  • HYDROGEN-PEROXIDE
  • FLAVONOIDS
  • BIOMARKERS
  • QUERCETIN

Cite this

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title = "The cocoa flavanol (-)-epicatechin protects the cortisol response.",
abstract = "Various health benefits of the cocoa flavanol (-)-epicatechin (EC) have been attributed to its antioxidant and anti-inflammatory potency. In the present study we investigated whether EC is able to prevent deterioration of the anti-inflammatory effect of the glucocorticoid (GC) cortisol in the presence of oxidative stress. It was found that cortisol reduces inflammation in differentiated monocytes. Oxidative stress extinguishes the anti-inflammatory effect of cortisol, leading to cortisol resistance. EC reduces intracellular oxidative stress as well as the development of cortisol resistance. This further deciphers the enigmatic mechanism of EC by which it exerts its anti-inflammatory and antioxidant action. The observed effect of the cocoa flavanol EC will especially be of relevance in pathophysiological conditions with increased oxidative stress and consequential GC resistance and provides a fundament for the rational use of dietary antioxidants.",
keywords = "Glucocorticoid resistance, Cortisol, (-)-Epicatechin, Anti-oxidant, Inflammation, Monocytes, OBSTRUCTIVE PULMONARY-DISEASE, OXIDATIVE STRESS, CORTICOSTEROID RESISTANCE, N-ACETYLCYSTEINE, CARDIOVASCULAR-DISEASE, ANTIOXIDANT PROPERTIES, HYDROGEN-PEROXIDE, FLAVONOIDS, BIOMARKERS, QUERCETIN",
author = "E.J. Ruijters and G.R. Haenen and A.R. Weseler and A. Bast",
year = "2014",
month = "1",
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doi = "10.1016/j.phrs.2013.11.004",
language = "English",
volume = "79",
pages = "28--33",
journal = "Pharmacological Research",
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The cocoa flavanol (-)-epicatechin protects the cortisol response. / Ruijters, E.J.; Haenen, G.R.; Weseler, A.R.; Bast, A.

In: Pharmacological Research, Vol. 79, 01.01.2014, p. 28-33.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The cocoa flavanol (-)-epicatechin protects the cortisol response.

AU - Ruijters, E.J.

AU - Haenen, G.R.

AU - Weseler, A.R.

AU - Bast, A.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Various health benefits of the cocoa flavanol (-)-epicatechin (EC) have been attributed to its antioxidant and anti-inflammatory potency. In the present study we investigated whether EC is able to prevent deterioration of the anti-inflammatory effect of the glucocorticoid (GC) cortisol in the presence of oxidative stress. It was found that cortisol reduces inflammation in differentiated monocytes. Oxidative stress extinguishes the anti-inflammatory effect of cortisol, leading to cortisol resistance. EC reduces intracellular oxidative stress as well as the development of cortisol resistance. This further deciphers the enigmatic mechanism of EC by which it exerts its anti-inflammatory and antioxidant action. The observed effect of the cocoa flavanol EC will especially be of relevance in pathophysiological conditions with increased oxidative stress and consequential GC resistance and provides a fundament for the rational use of dietary antioxidants.

AB - Various health benefits of the cocoa flavanol (-)-epicatechin (EC) have been attributed to its antioxidant and anti-inflammatory potency. In the present study we investigated whether EC is able to prevent deterioration of the anti-inflammatory effect of the glucocorticoid (GC) cortisol in the presence of oxidative stress. It was found that cortisol reduces inflammation in differentiated monocytes. Oxidative stress extinguishes the anti-inflammatory effect of cortisol, leading to cortisol resistance. EC reduces intracellular oxidative stress as well as the development of cortisol resistance. This further deciphers the enigmatic mechanism of EC by which it exerts its anti-inflammatory and antioxidant action. The observed effect of the cocoa flavanol EC will especially be of relevance in pathophysiological conditions with increased oxidative stress and consequential GC resistance and provides a fundament for the rational use of dietary antioxidants.

KW - Glucocorticoid resistance

KW - Cortisol

KW - (-)-Epicatechin

KW - Anti-oxidant

KW - Inflammation

KW - Monocytes

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - OXIDATIVE STRESS

KW - CORTICOSTEROID RESISTANCE

KW - N-ACETYLCYSTEINE

KW - CARDIOVASCULAR-DISEASE

KW - ANTIOXIDANT PROPERTIES

KW - HYDROGEN-PEROXIDE

KW - FLAVONOIDS

KW - BIOMARKERS

KW - QUERCETIN

U2 - 10.1016/j.phrs.2013.11.004

DO - 10.1016/j.phrs.2013.11.004

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JF - Pharmacological Research

SN - 1043-6618

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