The clinical role of host and bacterial-derived extracellular vesicles in pneumonia

A.L. Jung, B. Schmeck, M. Wiegand, K. Bedenbender, B.J. Benedikter*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

4 Citations (Web of Science)

Abstract

Pneumonia is among the leading causes of morbidity and mortality worldwide. Due to constant evolution of respiratory bacteria and viruses, development of drug resistance and emerging pathogens, it consti-tutes a considerable health care threat. To enable development of novel strategies to control pneumonia, a better understanding of the complex mechanisms of interaction between host cells and infecting patho-gens is vital. Here, we review the roles of host cell and bacterial-derived extracellular vesicles (EVs) in these interactions. We discuss clinical and experimental as well as pathogen-overarching and pathogen-specific evidence for common viral and bacterial elicitors of community-and hospital-acquired pneumonia. Finally, we highlight the potential of EVs for improved management of pneumonia patients and discuss the translational steps to be taken before they can be safely exploited as novel vac-cines, biomarkers, or therapeutics in clinical practice. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Original languageEnglish
Article number113811
Number of pages15
JournalAdvanced Drug Delivery Reviews
Volume176
DOIs
Publication statusPublished - 1 Sep 2021

Keywords

  • Outer membrane vesicles
  • Bacteria
  • Virus
  • ARDS
  • Sepsis
  • Vaccine
  • Biomarker
  • Therapeutics
  • OUTER-MEMBRANE VESICLES
  • NONTYPABLE HAEMOPHILUS-INFLUENZAE
  • RESPIRATORY-DISTRESS-SYNDROME
  • COMMUNITY-ACQUIRED PNEUMONIA
  • DNA-BINDING VESICLES
  • ACUTE LUNG INJURY
  • LEGIONELLA-PNEUMOPHILA
  • SECRETOME
  • EXOSOMES
  • VACCINE

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