The clinical burden of generalized osteoarthritis represented by self-reported health-related quality of life and activity limitations: a cross-sectional study

N. Cuperus, T.P.M. Vliet Vlieland, E.A.M. Mahler, C.C. Kersten, T.J. Hoogeboom, C.H.M. van den Ende

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Abstract

The involvement of multiple joints is common in osteoarthritis (OA), often referred to as generalized osteoarthritis (GOA). However, since research and practice mainly focus on a specific OA localization, the health status of patients with GOA is largely unknown. Therefore, we aimed to describe the clinical burden of GOA in terms of self-reported health-related quality of life (HRQoL) and activity limitations. In this cross-sectional study, individuals clinically diagnosed with GOA and referred to multidisciplinary treatment, completed questionnaires on socio-demographics, joint involvement, HRQoL (SF-36) and activity limitations (HAQ-DI). SF-36 physical (PCS) and mental component summary scores (MCS) were calculated using norm-based data. The patient's specific most important activity limitations were linked to the International Classification of Functioning, Disability and Health. A total of 147 patients participated [85 % female; mean (SD) age 60 (8) years]. The majority (93 %) had symptomatic OA in both the upper and lower extremities. Predominant joints with symptomatic OA were the hands (85 %) and knees (82 %). Mean (SD) SF-36 PCS and MCS scores were 37 (7) and 48 (10), respectively, showing a broad impact of GOA on the physical component of health. The mean (SD) HAQ-DI score was 1.27 (0.50) indicating moderate to severe functional limitations. Activities concerning mobility and domestic life were considered most important activity limitations, especially walking. The results show a high clinical burden of GOA in terms of HRQoL and activity limitations. This study points to the need of developing non-pharmacological interventions for patients with GOA that should target on improving the physical component of health and mobility limitations.

Original languageEnglish
Pages (from-to)871-877
Number of pages7
JournalRheumatology International
Volume35
Issue number5
DOIs
Publication statusPublished - May 2015

Keywords

  • Generalized osteoarthritis
  • Health-related quality of life
  • Activity limitations
  • Health status
  • JOINT-PAIN COMORBIDITY
  • LOW-BACK-PAIN
  • KNEE OSTEOARTHRITIS
  • INTERNATIONAL CLASSIFICATION
  • SYMPTOMATIC OSTEOARTHRITIS
  • ASSESSMENT QUESTIONNAIRE
  • DISABILITY
  • OUTCOMES
  • SF-36
  • HIP

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