The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings

G. Cavaletti; D. R. Cornblath; I. S. J. Merkies; T. J. Postma; E. Rossi; B. Frigeni; P. Alberti; J. Bruna; R. Velasco; A. A. Argyriou; H. P. Kalofonos; D. Psimaras; D. Ricard; A. Pace; E. Galie; C. Briani; C. Dalla Torre; C. G. Faber; R. I. Lalisang; W. Boogerd; D. Brandsma; S. Koeppen; J. Hense; D. Storey; S. Kerrigan; A. Schenone; S. Fabbri; M. G. Valsecchi

doi:10.1093/annonc/mds329

The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings

G. Cavaletti^*
, D. R. Cornblath
, I. S. J. Merkies
, T. J. Postma
, E. Rossi
, B. Frigeni
, P. Alberti
, J. Bruna
, R. Velasco
, A. A. Argyriou
, H. P. Kalofonos
, D. Psimaras
, D. Ricard
, A. Pace
, E. Galie
, C. Briani
, C. Dalla Torre
, C. G. Faber
, R. I. Lalisang
, W. Boogerd

D. Brandsma, S. Koeppen, J. Hense, D. Storey, S. Kerrigan, A. Schenone, S. Fabbri, M. G. Valsecchi

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting complication of cancer treatment. Thus far, the impact of CIPN has not been studied in a systematic clinimetric manner. The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study. After literature review and a consensus meeting among experts, face/content validity were obtained for the following selected scales: the National Cancer Institute-Common Toxicity Criteria (NCI-CTC), the Total Neuropathy Score clinical version (TNSc), the modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sumscore (mISS), the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and CIPN20 quality-of-life measures. A total of 281 patients with stable CIPN were examined. Validity (correlation) and reliability studies were carried out. Good inter-/intra-observer scores were obtained for the TNSc, mISS, and NCI-CTC sensory/motor subscales. Test-retest values were also good for the EORTC QLQ-C30 and CIPN20. Acceptable validity scores were obtained through the correlation among the measures. Good validity and reliability scores were demonstrated for the set of selected impairment and quality-of-life outcome measures in CIPN. Future studies are planned to investigate the responsiveness aspects of these measures.

Original language	English
Pages (from-to)	454-462
Number of pages	9
Journal	Annals of Oncology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1093/annonc/mds329
Publication status	Published - Feb 2013

Keywords

assessment
chemotherapy
clinimetrics
peripheral neuropathy
reliability
validity

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Cavaletti, G., Cornblath, D. R., Merkies, I. S. J., Postma, T. J., Rossi, E., Frigeni, B., Alberti, P., Bruna, J., Velasco, R., Argyriou, A. A., Kalofonos, H. P., Psimaras, D., Ricard, D., Pace, A., Galie, E., Briani, C., Dalla Torre, C., Faber, C. G., Lalisang, R. I., ... Valsecchi, M. G. (2013). The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings. Annals of Oncology, 24(2), 454-462. https://doi.org/10.1093/annonc/mds329

@article{f01fd2e78c8d4aee94aa05d929ed599c,

title = "The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings",

abstract = "Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting complication of cancer treatment. Thus far, the impact of CIPN has not been studied in a systematic clinimetric manner. The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study. After literature review and a consensus meeting among experts, face/content validity were obtained for the following selected scales: the National Cancer Institute-Common Toxicity Criteria (NCI-CTC), the Total Neuropathy Score clinical version (TNSc), the modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sumscore (mISS), the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and CIPN20 quality-of-life measures. A total of 281 patients with stable CIPN were examined. Validity (correlation) and reliability studies were carried out. Good inter-/intra-observer scores were obtained for the TNSc, mISS, and NCI-CTC sensory/motor subscales. Test-retest values were also good for the EORTC QLQ-C30 and CIPN20. Acceptable validity scores were obtained through the correlation among the measures. Good validity and reliability scores were demonstrated for the set of selected impairment and quality-of-life outcome measures in CIPN. Future studies are planned to investigate the responsiveness aspects of these measures.",

keywords = "assessment, chemotherapy, clinimetrics, peripheral neuropathy, reliability, validity",

author = "G. Cavaletti and Cornblath, \{D. R.\} and Merkies, \{I. S. J.\} and Postma, \{T. J.\} and E. Rossi and B. Frigeni and P. Alberti and J. Bruna and R. Velasco and Argyriou, \{A. A.\} and Kalofonos, \{H. P.\} and D. Psimaras and D. Ricard and A. Pace and E. Galie and C. Briani and \{Dalla Torre\}, C. and Faber, \{C. G.\} and Lalisang, \{R. I.\} and W. Boogerd and D. Brandsma and S. Koeppen and J. Hense and D. Storey and S. Kerrigan and A. Schenone and S. Fabbri and Valsecchi, \{M. G.\}",

year = "2013",

month = feb,

doi = "10.1093/annonc/mds329",

language = "English",

volume = "24",

pages = "454--462",

journal = "Annals of Oncology",

issn = "0923-7534",

publisher = "Elsevier Ltd",

number = "2",

}

Cavaletti, G, Cornblath, DR, Merkies, ISJ, Postma, TJ, Rossi, E, Frigeni, B, Alberti, P, Bruna, J, Velasco, R, Argyriou, AA, Kalofonos, HP, Psimaras, D, Ricard, D, Pace, A, Galie, E, Briani, C, Dalla Torre, C, Faber, CG , Lalisang, RI, Boogerd, W, Brandsma, D, Koeppen, S, Hense, J, Storey, D, Kerrigan, S, Schenone, A, Fabbri, S & Valsecchi, MG 2013, 'The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings', Annals of Oncology, vol. 24, no. 2, pp. 454-462. https://doi.org/10.1093/annonc/mds329

TY - JOUR

T1 - The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings

AU - Cavaletti, G.

AU - Cornblath, D. R.

AU - Merkies, I. S. J.

AU - Postma, T. J.

AU - Rossi, E.

AU - Frigeni, B.

AU - Alberti, P.

AU - Bruna, J.

AU - Velasco, R.

AU - Argyriou, A. A.

AU - Kalofonos, H. P.

AU - Psimaras, D.

AU - Ricard, D.

AU - Pace, A.

AU - Galie, E.

AU - Briani, C.

AU - Dalla Torre, C.

AU - Faber, C. G.

AU - Lalisang, R. I.

AU - Boogerd, W.

AU - Brandsma, D.

AU - Koeppen, S.

AU - Hense, J.

AU - Storey, D.

AU - Kerrigan, S.

AU - Schenone, A.

AU - Fabbri, S.

AU - Valsecchi, M. G.

PY - 2013/2

Y1 - 2013/2

N2 - Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting complication of cancer treatment. Thus far, the impact of CIPN has not been studied in a systematic clinimetric manner. The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study. After literature review and a consensus meeting among experts, face/content validity were obtained for the following selected scales: the National Cancer Institute-Common Toxicity Criteria (NCI-CTC), the Total Neuropathy Score clinical version (TNSc), the modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sumscore (mISS), the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and CIPN20 quality-of-life measures. A total of 281 patients with stable CIPN were examined. Validity (correlation) and reliability studies were carried out. Good inter-/intra-observer scores were obtained for the TNSc, mISS, and NCI-CTC sensory/motor subscales. Test-retest values were also good for the EORTC QLQ-C30 and CIPN20. Acceptable validity scores were obtained through the correlation among the measures. Good validity and reliability scores were demonstrated for the set of selected impairment and quality-of-life outcome measures in CIPN. Future studies are planned to investigate the responsiveness aspects of these measures.

AB - Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting complication of cancer treatment. Thus far, the impact of CIPN has not been studied in a systematic clinimetric manner. The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study. After literature review and a consensus meeting among experts, face/content validity were obtained for the following selected scales: the National Cancer Institute-Common Toxicity Criteria (NCI-CTC), the Total Neuropathy Score clinical version (TNSc), the modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sumscore (mISS), the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and CIPN20 quality-of-life measures. A total of 281 patients with stable CIPN were examined. Validity (correlation) and reliability studies were carried out. Good inter-/intra-observer scores were obtained for the TNSc, mISS, and NCI-CTC sensory/motor subscales. Test-retest values were also good for the EORTC QLQ-C30 and CIPN20. Acceptable validity scores were obtained through the correlation among the measures. Good validity and reliability scores were demonstrated for the set of selected impairment and quality-of-life outcome measures in CIPN. Future studies are planned to investigate the responsiveness aspects of these measures.

KW - assessment

KW - chemotherapy

KW - clinimetrics

KW - peripheral neuropathy

KW - reliability

KW - validity

U2 - 10.1093/annonc/mds329

DO - 10.1093/annonc/mds329

M3 - Article

C2 - 22910842

SN - 0923-7534

VL - 24

SP - 454

EP - 462

JO - Annals of Oncology

JF - Annals of Oncology

IS - 2

ER -

The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings

Abstract

Keywords

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