The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial

Firas Al-Ali; Olvert A. Berkhemer; Wina P. Yousman; John J. Elias; Evin N. Bender; Hester F. Lingsma; Aad van der Lugt; Diederik W. J. Dippel; Yvo B. W. E. M. Roos; Robert J. van Oostenbrugge; Wim H. van Zwam; William P. Dillon; Charles B. L. M. Majoie

doi:10.1161/STROKEAHA.116.013513

The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial

Firas Al-Ali^*, Olvert A. Berkhemer, Wina P. Yousman, John J. Elias, Evin N. Bender, Hester F. Lingsma, Aad van der Lugt, Diederik W. J. Dippel, Yvo B. W. E. M. Roos, Robert J. van Oostenbrugge, Wim H. van Zwam, William P. Dillon, Charles B. L. M. Majoie

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and Purpose The capillary index score (CIS) is based on the hypothesis that areas lacking capillary blush on pretreatment cerebral digital subtraction angiograms correspond to nonviable cerebral tissue. Methods Pretreatment digital subtraction angiograms and post-treatment noncontrast enhanced computed tomographic scans from the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial were evaluated for areas lacking capillary blush and with tissue hypodensity, respectively. Because the superior and middle zones of the CIS correspond to the 7 cerebral cortex regions of the Alberta Stroke Program Early CT (ASPECT) score, capillary blush was scored in these 2 zones (0-2), called sub-CIS, and compared with the ASPECT score in these 7 regions (0-7), called hypodensity score. The presence and extent of hypodensity were compared between sub-CIS zones with contingency tables and nonparametric comparisons between groups, respectively. Results On the basis of a sample size of 50 subjects, 100% with sub-CIS

Original language	English
Pages (from-to)	2286-2291
Journal	Stroke
Volume	47
Issue number	9
DOIs	https://doi.org/10.1161/STROKEAHA.116.013513
Publication status	Published - Sept 2016

Keywords

cerebral cortex
infarction
stroke
tissue

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Al-Ali, F., Berkhemer, O. A., Yousman, W. P., Elias, J. J., Bender, E. N., Lingsma, H. F., van der Lugt, A., Dippel, D. W. J., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., van Zwam, W. H., Dillon, W. P., & Majoie, C. B. L. M. (2016). The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial. Stroke, 47(9), 2286-2291. https://doi.org/10.1161/STROKEAHA.116.013513

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title = "The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial",

abstract = "Background and Purpose The capillary index score (CIS) is based on the hypothesis that areas lacking capillary blush on pretreatment cerebral digital subtraction angiograms correspond to nonviable cerebral tissue. Methods Pretreatment digital subtraction angiograms and post-treatment noncontrast enhanced computed tomographic scans from the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial were evaluated for areas lacking capillary blush and with tissue hypodensity, respectively. Because the superior and middle zones of the CIS correspond to the 7 cerebral cortex regions of the Alberta Stroke Program Early CT (ASPECT) score, capillary blush was scored in these 2 zones (0-2), called sub-CIS, and compared with the ASPECT score in these 7 regions (0-7), called hypodensity score. The presence and extent of hypodensity were compared between sub-CIS zones with contingency tables and nonparametric comparisons between groups, respectively. Results On the basis of a sample size of 50 subjects, 100% with sub-CIS ",

keywords = "cerebral cortex, infarction, stroke, tissue",

author = "Firas Al-Ali and Berkhemer, {Olvert A.} and Yousman, {Wina P.} and Elias, {John J.} and Bender, {Evin N.} and Lingsma, {Hester F.} and {van der Lugt}, Aad and Dippel, {Diederik W. J.} and Roos, {Yvo B. W. E. M.} and {van Oostenbrugge}, {Robert J.} and {van Zwam}, {Wim H.} and Dillon, {William P.} and Majoie, {Charles B. L. M.}",

year = "2016",

month = sep,

doi = "10.1161/STROKEAHA.116.013513",

language = "English",

volume = "47",

pages = "2286--2291",

journal = "Stroke",

issn = "0039-2499",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

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Al-Ali, F, Berkhemer, OA, Yousman, WP, Elias, JJ, Bender, EN, Lingsma, HF, van der Lugt, A, Dippel, DWJ, Roos, YBWEM, van Oostenbrugge, RJ , van Zwam, WH, Dillon, WP & Majoie, CBLM 2016, 'The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial', Stroke, vol. 47, no. 9, pp. 2286-2291. https://doi.org/10.1161/STROKEAHA.116.013513

The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial. / Al-Ali, Firas; Berkhemer, Olvert A.; Yousman, Wina P. et al.
In: Stroke, Vol. 47, No. 9, 09.2016, p. 2286-2291.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - The Capillary Index Score as a Marker of Viable Cerebral Tissue

T2 - Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial

AU - Al-Ali, Firas

AU - Berkhemer, Olvert A.

AU - Yousman, Wina P.

AU - Elias, John J.

AU - Bender, Evin N.

AU - Lingsma, Hester F.

AU - van der Lugt, Aad

AU - Dippel, Diederik W. J.

AU - Roos, Yvo B. W. E. M.

AU - van Oostenbrugge, Robert J.

AU - van Zwam, Wim H.

AU - Dillon, William P.

AU - Majoie, Charles B. L. M.

PY - 2016/9

Y1 - 2016/9

N2 - Background and Purpose The capillary index score (CIS) is based on the hypothesis that areas lacking capillary blush on pretreatment cerebral digital subtraction angiograms correspond to nonviable cerebral tissue. Methods Pretreatment digital subtraction angiograms and post-treatment noncontrast enhanced computed tomographic scans from the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial were evaluated for areas lacking capillary blush and with tissue hypodensity, respectively. Because the superior and middle zones of the CIS correspond to the 7 cerebral cortex regions of the Alberta Stroke Program Early CT (ASPECT) score, capillary blush was scored in these 2 zones (0-2), called sub-CIS, and compared with the ASPECT score in these 7 regions (0-7), called hypodensity score. The presence and extent of hypodensity were compared between sub-CIS zones with contingency tables and nonparametric comparisons between groups, respectively. Results On the basis of a sample size of 50 subjects, 100% with sub-CIS

AB - Background and Purpose The capillary index score (CIS) is based on the hypothesis that areas lacking capillary blush on pretreatment cerebral digital subtraction angiograms correspond to nonviable cerebral tissue. Methods Pretreatment digital subtraction angiograms and post-treatment noncontrast enhanced computed tomographic scans from the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial were evaluated for areas lacking capillary blush and with tissue hypodensity, respectively. Because the superior and middle zones of the CIS correspond to the 7 cerebral cortex regions of the Alberta Stroke Program Early CT (ASPECT) score, capillary blush was scored in these 2 zones (0-2), called sub-CIS, and compared with the ASPECT score in these 7 regions (0-7), called hypodensity score. The presence and extent of hypodensity were compared between sub-CIS zones with contingency tables and nonparametric comparisons between groups, respectively. Results On the basis of a sample size of 50 subjects, 100% with sub-CIS

KW - cerebral cortex

KW - infarction

KW - stroke

KW - tissue

U2 - 10.1161/STROKEAHA.116.013513

DO - 10.1161/STROKEAHA.116.013513

M3 - Article

C2 - 27491736

SN - 0039-2499

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SP - 2286

EP - 2291

JO - Stroke

JF - Stroke

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Al-Ali F, Berkhemer OA, Yousman WP, Elias JJ, Bender EN, Lingsma HF et al. The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial. Stroke. 2016 Sept;47(9):2286-2291. doi: 10.1161/STROKEAHA.116.013513