The Calibrated Automated Thrombogram (CAT): A universal routine test for hyper- and hypocoagulability

H.C. Hemker*, P. Giesen, R. Al Dieri, V. Regnault, E. de Smed, R. Wagenvoord, T. Lecompte, S. Beguin

*Corresponding author for this work

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    By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.
    Original languageEnglish
    Pages (from-to)249-253
    Number of pages5
    JournalPathophysiology of Haemostasis and Thrombosis
    Issue number5-6
    Publication statusPublished - 2002

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