TY - JOUR
T1 - The Calibrated Automated Thrombogram (CAT)
T2 - A universal routine test for hyper- and hypocoagulability
AU - Hemker, H.C.
AU - Giesen, P.
AU - Al Dieri, R.
AU - Regnault, V.
AU - de Smed, E.
AU - Wagenvoord, R.
AU - Lecompte, T.
AU - Beguin, S.
PY - 2002
Y1 - 2002
N2 - By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.
AB - By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.
U2 - 10.1159/000073575
DO - 10.1159/000073575
M3 - Article
C2 - 13679651
SN - 1424-8832
VL - 32
SP - 249
EP - 253
JO - Pathophysiology of Haemostasis and Thrombosis
JF - Pathophysiology of Haemostasis and Thrombosis
IS - 5-6
ER -