The Calibrated Automated Thrombogram (CAT): A universal routine test for hyper- and hypocoagulability

H.C. Hemker; P. Giesen; R. Al Dieri; V. Regnault; E. de Smed; R. Wagenvoord; T. Lecompte; S. Beguin

doi:10.1159/000073575

The Calibrated Automated Thrombogram (CAT): A universal routine test for hyper- and hypocoagulability

H.C. Hemker^*, P. Giesen, R. Al Dieri, V. Regnault, E. de Smed, R. Wagenvoord, T. Lecompte, S. Beguin

^*Corresponding author for this work

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Abstract

By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.

Original language	English
Pages (from-to)	249-253
Number of pages	5
Journal	Pathophysiology of Haemostasis and Thrombosis
Volume	32
Issue number	5-6
DOIs	https://doi.org/10.1159/000073575
Publication status	Published - 2002

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title = "The Calibrated Automated Thrombogram (CAT): A universal routine test for hyper- and hypocoagulability",

abstract = "By using a {"}slow{"} fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting {"}Thrombogram{"} in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.",

author = "H.C. Hemker and P. Giesen and {Al Dieri}, R. and V. Regnault and {de Smed}, E. and R. Wagenvoord and T. Lecompte and S. Beguin",

year = "2002",

doi = "10.1159/000073575",

language = "English",

volume = "32",

pages = "249--253",

journal = "Pathophysiology of Haemostasis and Thrombosis",

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publisher = "S. Karger AG",

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TY - JOUR

T1 - The Calibrated Automated Thrombogram (CAT)

T2 - A universal routine test for hyper- and hypocoagulability

AU - Hemker, H.C.

AU - Giesen, P.

AU - Al Dieri, R.

AU - Regnault, V.

AU - de Smed, E.

AU - Wagenvoord, R.

AU - Lecompte, T.

AU - Beguin, S.

PY - 2002

Y1 - 2002

N2 - By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.

AB - By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot.C and S deficiency, factor V Leiden, oral contraceptives).In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic- thrombotic mechanism of the blood. Copyright (C) 2002 S. Karger AG. Basel.

U2 - 10.1159/000073575

DO - 10.1159/000073575

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JO - Pathophysiology of Haemostasis and Thrombosis

JF - Pathophysiology of Haemostasis and Thrombosis

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ER -