The Burden of Peritoneal Metastases from Gastric Cancer: A Systematic Review on the Incidence, Risk Factors and Survival

A. Rijken, R.J. Lurvink, M.D.P. Luyer, G.A.P. Nieuwenhuijzen, F.N. van Erning, J.W. van Sandick, I.H.J.T. de Hingh*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

6 Citations (Web of Science)

Abstract

The peritoneum is a common metastatic site in gastric cancer. This systematic review provides an overview of the incidence, risk factors and survival of synchronous peritoneal metastases from gastric cancer. A systematic search was performed to identify studies wherein the incidence, risk factors and survival of gastric cancer with peritoneal metastases were investigated. Of all 38 potentially eligible studies, 17 studies were included based on the eligibility criteria. The incidence of synchronous gastric peritoneal metastases was reviewed for population-based studies (10-21%), for observational cohort studies (2-15%) and for surgical cohort studies (13-40%). Potential risk factors for synchronous gastric peritoneal metastases were younger age, non-cardia gastric cancer, female sex, signet ring cell carcinoma, diffuse type histology or linitis plastica, T4 stage, Hispanic ethnicity and more than one metastatic location. Synchronous peritoneal metastases are commonly diagnosed in patients with gastric cancer with an incidence up to 21% in recent population-based studies. Furthermore, prognosis of patients with gastric peritoneal metastases is poor with median overall survival ranging from 2 to 9 months. The high incidence and poor prognosis require intensive research on diagnostic features and effective treatment options to improve survival.
Original languageEnglish
Article number4882
Number of pages16
JournalJournal of Clinical Medicine
Volume10
Issue number21
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • peritoneal metastases
  • gastric cancer
  • incidence
  • treatment
  • survival
  • HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY
  • STAGING LAPAROSCOPY
  • CLINICOPATHOLOGICAL CHARACTERISTICS
  • ADENOCARCINOMA
  • CARCINOMA
  • YOUNG
  • GASTROESOPHAGEAL
  • EXPERIENCE
  • PROGNOSIS
  • SURGERY

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