The Brain under Attack: Autoantibodies in Psychotic Disorders

Carolin Hoffmann

Research output: ThesisDoctoral ThesisInternal

Abstract

This dissertation investigates the hypothesis whether in a small subgroup of patients with psychotic symptoms, the immune system is attacking the brain. Some autoantibodies have been reported to target specific proteins in the brain and thereby induce neurological and psychotic symptoms. Our results indicate that the presence of these previously described autoantibodies are very rare in the blood of patients with psychotic diagnoses and that the currently used diagnostic methods are of limited use in these cohorts. However, we identified the presence of novel autoantibodies with unclear target in the brain. We further describe two methods to clone autoantibodies from patients immune-cells to be able to produce autoantibodies in the laboratory for further analysis of their pathological function.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Martinez Martinez, Pilar, Supervisor
  • Rutten, Bart, Supervisor
  • van Os, Jim, Supervisor
Award date20 Apr 2018
Publication statusPublished - 2018

Keywords

  • autoimmunity
  • psychosis
  • antibody cloning
  • autoimmune encephalitis

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