The biochemistry of blood coagulation

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    Abstract

    Thrombin is the central enzyme in hemostasis and thrombosis. The study of its generation has been prompted by the many diseases in which hemostasis and thrombosis play a role. The bleeding disorders like hemophilia a are obvious but rare examples. Much more common is the other extreme: the excessive and unknown reaction of the hemostatic process known as thrombosis and its sequel embolism. Thrombosis on basis of atherosclerosis and thrombosis in the veins are very important pathological processes. Evidence is rapidly accumulating that not only (micro)thrombosis is an important complication of atherosclerosis but also plays a role, maybe even the main role, in the genesis of atherosclerosis. Thrombosis in one form or another may therefore be considered to be a key event in well over half of all deaths in the western society, including well-known diseases as coronary infarction, stroke, circulation disturbances in the legs, kidney disease etc. Thrombin generation therefore is a suitable subject of research in a biochemistry department of a medical faculty. On the other hand it shows so many novel features not recognized in enzymology until now, that it cannot fail to interest even the most basicly interested biochemist.keywordsfactor viiifactor versusplatelet reactionglutamic acid residuesmall substratethese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
    Original languageEnglish
    Title of host publicationBloodtransfusion and Problems of Bleeding
    EditorsCees Smit Sibinga, P.C. Das, J.J. van Loghem
    Place of PublicationNetherlands
    PublisherSpringer
    Pages3-14
    Number of pages12
    Edition1
    ISBN (Electronic)9789400976924
    ISBN (Print)9789400976948
    DOIs
    Publication statusPublished - 1982

    Publication series

    SeriesDevelopments in hematology and immunology
    Volume5
    ISSN0167-9201

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