The Basolateral Amygdalae and Frontotemporal Network Functions for Threat Perception

Ruud Hortensius, David Terburg, Barak Morgan, Dan J. Stein, Jack van Honk, Beatrice de Gelder

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Although the amygdalae play a central role in threat perception and reactions, the direct contributions of the amygdalae to specific aspects of threat perception, from ambiguity resolution to reflexive or deliberate action, remain ill understood in humans. Animal studies show that a detailed understanding requires a focus on the different subnuclei, which is not yet achieved in human research. Given the limits of human imaging methods, the crucial contribution needs to come from individuals with exclusive and selective amygdalae lesions. The current study investigated the role of the basolateral amygdalae and their connection with associated frontal and temporal networks in the automatic perception of threat. Functional activation and connectivity of five individuals with Urbach-Wiethe disease with focal basolateral amygdalae damage and 12 matched controls were measured with functional MRI while they attended to the facial expression of a threatening face-body compound stimuli. Basolateral amygdalae damage was associated with decreased activation in the temporal pole but increased activity in the ventral and dorsal medial prefrontal and medial orbitofrontal cortex. This dissociation between the prefrontal and temporal networks was also present in the connectivity maps. Our results contribute to a dynamic, multirole, subnuclei-based perspective on the involvement of the amygdalae in fear perception. Damage to the basolateral amygdalae decreases activity in the temporal network while increasing activity in the frontal network, thereby potentially triggering a switch from resolving ambiguity to dysfunctional threat signaling and regulation, resulting in hypersensitivity to threat.

Original languageEnglish
Article numbere0314-16.2016
Number of pages15
JournaleNeuro
Volume4
Issue number1
DOIs
Publication statusPublished - 5 Apr 2017

Keywords

  • BRAIN-REGIONS
  • GENERALIZED ANXIETY DISORDER
  • SURPRISED FACES
  • VISUAL CORTICAL ACTIVATION
  • BODILY EXPRESSIONS
  • Urbach-Wiethe disease
  • amygdalae
  • PARIETAL CORTEX
  • FEAR GENERALIZATION
  • emotion
  • MEDIAL PREFRONTAL CORTEX
  • threat
  • EMOTIONAL EXPRESSIONS
  • basolateral amygdalae
  • TEMPORAL POLE

Cite this

Hortensius, R., Terburg, D., Morgan, B., Stein, D. J., van Honk, J., & de Gelder, B. (2017). The Basolateral Amygdalae and Frontotemporal Network Functions for Threat Perception. eNeuro, 4(1), [e0314-16.2016]. https://doi.org/10.1523/ENEURO.0314-16.2016
Hortensius, Ruud ; Terburg, David ; Morgan, Barak ; Stein, Dan J. ; van Honk, Jack ; de Gelder, Beatrice. / The Basolateral Amygdalae and Frontotemporal Network Functions for Threat Perception. In: eNeuro. 2017 ; Vol. 4, No. 1.
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Hortensius, R, Terburg, D, Morgan, B, Stein, DJ, van Honk, J & de Gelder, B 2017, 'The Basolateral Amygdalae and Frontotemporal Network Functions for Threat Perception', eNeuro, vol. 4, no. 1, e0314-16.2016. https://doi.org/10.1523/ENEURO.0314-16.2016

The Basolateral Amygdalae and Frontotemporal Network Functions for Threat Perception. / Hortensius, Ruud; Terburg, David; Morgan, Barak; Stein, Dan J.; van Honk, Jack; de Gelder, Beatrice.

In: eNeuro, Vol. 4, No. 1, e0314-16.2016, 05.04.2017.

Research output: Contribution to journalArticleAcademicpeer-review

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KW - EMOTIONAL EXPRESSIONS

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KW - TEMPORAL POLE

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