The Association of Chemokine Gene Polymorphisms with VKH and Behcet's Disease in a Chinese Han Population

Yang Huang; Hongsong Yu; Qingfeng Cao; Jing Deng; Xinyue Huang; Aize Kijlstra; Peizeng Yang

doi:10.1155/2017/1274960

The Association of Chemokine Gene Polymorphisms with VKH and Behcet's Disease in a Chinese Han Population

Yang Huang, Hongsong Yu, Qingfeng Cao, Jing Deng, Xinyue Huang, Aize Kijlstra, Peizeng Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To investigate the association of chemokine gene polymorphisms and Behcet's disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. In this study, p(uncorr) values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease. However, after Bonferroni correction, the 26 investigated SNPs showed no significant differences in genetic variants, including genotype and allele frequencies, between BD or VKH disease patients and healthy individuals. Haplotype analysis for the chemokine genes showed a significant association with the TC haplotype of CXCL12 in VKH. Stratified gender analysis and genotype-phenotype analysis were conducted to analyze the association of the 26 SNPs of 12 chemokine genes with BD and VKH disease. However, no significant association was observed after Bonferroni correction. This study showed no association of 26 SNPs in 12 chemokine genes with both BD and VKH disease in a Chinese Han population.

Original language	English
Article number	1274960
Number of pages	8
Journal	BioMed Research International
Volume	2017
DOIs	https://doi.org/10.1155/2017/1274960
Publication status	Published - 2017

Keywords

SINGLE-NUCLEOTIDE POLYMORPHISM
SYSTEMIC-LUPUS-ERYTHEMATOSUS
KOYANAGI-HARADA-DISEASE
MULTIPLE-SCLEROSIS
UVEITIS
SUSCEPTIBILITY
INFLAMMATION
METAANALYSIS
CLUSTER
GENDER

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Cite this

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title = "The Association of Chemokine Gene Polymorphisms with VKH and Behcet's Disease in a Chinese Han Population",

abstract = "To investigate the association of chemokine gene polymorphisms and Behcet's disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. In this study, p(uncorr) values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease. However, after Bonferroni correction, the 26 investigated SNPs showed no significant differences in genetic variants, including genotype and allele frequencies, between BD or VKH disease patients and healthy individuals. Haplotype analysis for the chemokine genes showed a significant association with the TC haplotype of CXCL12 in VKH. Stratified gender analysis and genotype-phenotype analysis were conducted to analyze the association of the 26 SNPs of 12 chemokine genes with BD and VKH disease. However, no significant association was observed after Bonferroni correction. This study showed no association of 26 SNPs in 12 chemokine genes with both BD and VKH disease in a Chinese Han population.",

keywords = "SINGLE-NUCLEOTIDE POLYMORPHISM, SYSTEMIC-LUPUS-ERYTHEMATOSUS, KOYANAGI-HARADA-DISEASE, MULTIPLE-SCLEROSIS, UVEITIS, SUSCEPTIBILITY, INFLAMMATION, METAANALYSIS, CLUSTER, GENDER",

author = "Yang Huang and Hongsong Yu and Qingfeng Cao and Jing Deng and Xinyue Huang and Aize Kijlstra and Peizeng Yang",

year = "2017",

doi = "10.1155/2017/1274960",

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T1 - The Association of Chemokine Gene Polymorphisms with VKH and Behcet's Disease in a Chinese Han Population

AU - Huang, Yang

AU - Yu, Hongsong

AU - Cao, Qingfeng

AU - Deng, Jing

AU - Huang, Xinyue

AU - Kijlstra, Aize

AU - Yang, Peizeng

PY - 2017

Y1 - 2017

N2 - To investigate the association of chemokine gene polymorphisms and Behcet's disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. In this study, p(uncorr) values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease. However, after Bonferroni correction, the 26 investigated SNPs showed no significant differences in genetic variants, including genotype and allele frequencies, between BD or VKH disease patients and healthy individuals. Haplotype analysis for the chemokine genes showed a significant association with the TC haplotype of CXCL12 in VKH. Stratified gender analysis and genotype-phenotype analysis were conducted to analyze the association of the 26 SNPs of 12 chemokine genes with BD and VKH disease. However, no significant association was observed after Bonferroni correction. This study showed no association of 26 SNPs in 12 chemokine genes with both BD and VKH disease in a Chinese Han population.

AB - To investigate the association of chemokine gene polymorphisms and Behcet's disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population. A case-control study was performed. Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays. In this study, p(uncorr) values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease. However, after Bonferroni correction, the 26 investigated SNPs showed no significant differences in genetic variants, including genotype and allele frequencies, between BD or VKH disease patients and healthy individuals. Haplotype analysis for the chemokine genes showed a significant association with the TC haplotype of CXCL12 in VKH. Stratified gender analysis and genotype-phenotype analysis were conducted to analyze the association of the 26 SNPs of 12 chemokine genes with BD and VKH disease. However, no significant association was observed after Bonferroni correction. This study showed no association of 26 SNPs in 12 chemokine genes with both BD and VKH disease in a Chinese Han population.

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KW - SUSCEPTIBILITY

KW - INFLAMMATION

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