The association of changes in body mass index and metabolic parameters between adults with overweight or obesity and their children in a family-based randomized trial (DiOGenes)

M.D. Pang, H. Yilmaz, A. Astrup, E.E. Blaak, M.A. Baak*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background Family-based approaches have been reported to be effective in improving overweight or obesity in children. Objectives To investigate the relationship of changes in body mass index and metabolic parameters between adults with overweight or obesity and their children during a weight-maintenance family-based dietary intervention. Methods In a multicentre randomized controlled trial, families with at least one parent with overweight or obesity and one healthy child aged between 5 and 18 years, of which the parents completed an 8-week weight-loss phase successfully, were randomized into five different dietary intervention groups to achieve weight maintenance for 6 months. Anthropometric parameters and body composition were measured and blood samples were collected before and after the dietary intervention. Data were analysed using Pearson correlation coefficient analyses and multiple linear regression analysis adjusted for diet group, centre, child's sex and age. Results A positive association was found between the change in body mass index (BMI) of the mother and change in BMI-for-age Z-score of first and second child (std beta = 0.248, p = 0.000; std beta = 0.326, p = 0.000, respectively). The change in BMI of the father was only significantly associated with the change in BMI-for-age Z-score of first child (std beta = 0.186, p = 0.031). No consistent pattern of associations between parents and children was found for homeostatic model assessment for insulin resistance, fasting glucose and fasting insulin. Conclusion This study supports the inclusion of parents into family-based dietary approaches for weight management of their children regardless of the child's weight status in eight different countries throughout Europe.
Original languageEnglish
Article numbere12884
Number of pages11
JournalPediatric Obesity
Issue number5
Early online date30 Dec 2021
Publication statusPublished - May 2022


  • children
  • family
  • lifestyle intervention
  • metabolic health
  • obesity
  • weight loss
  • BMI
  • RISK

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