TY - JOUR
T1 - The association between waist circumference and risk of mortality considering body mass index in 65-to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons
AU - de Hollander, Ellen L.
AU - Bemelmans, Wanda J.E.
AU - Boshuizen, Hendriek C.
AU - Friedrich, Nele
AU - Wallaschofski, Henri
AU - Guallar-Castillon, Pilar
AU - Walter, Stefan
AU - Zillikens, M. Carola
AU - Rosengren, Annika
AU - Lissner, Lauren
AU - Bassett, Julie K.
AU - Giles, Graham G.
AU - Orsini, Nicola
AU - Heim, Noor
AU - Visser, Marjolein
AU - WC elderly collaborators
AU - Stehouwer, Coen
AU - de Groot, Lisette C. P. G. M.
PY - 2012/6
Y1 - 2012/6
N2 - For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined.Age- and smoking-adjusted relative risks (RRs) of mortality associated with WC-BMI categories and continuous WC (including WC and WC(2)) were calculated by the investigators and pooled by means of random-effects models.During a 5-year-follow-up of 32?678 men and 25?931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: ?102 cm, women: ?88 cm) was associated with increased all-cause mortality RRs for those in the 'healthy' weight {1.7 [95% confidence interval (CI): 1.2-2.2], 1.7 (95% CI: 1.3-2.3)}, overweight [1.1(95% CI: 1.0-1.3), 1.4 (95%: 1.1-1.7)] and obese [1.1 (95% CI: 1.0-1.3), 1.6 (95% CI: 1.3-1.9)] BMI category compared with the 'healthy' weight (20-24.9 kg/m(2)) and a small WC (
AB - For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined.Age- and smoking-adjusted relative risks (RRs) of mortality associated with WC-BMI categories and continuous WC (including WC and WC(2)) were calculated by the investigators and pooled by means of random-effects models.During a 5-year-follow-up of 32?678 men and 25?931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: ?102 cm, women: ?88 cm) was associated with increased all-cause mortality RRs for those in the 'healthy' weight {1.7 [95% confidence interval (CI): 1.2-2.2], 1.7 (95% CI: 1.3-2.3)}, overweight [1.1(95% CI: 1.0-1.3), 1.4 (95%: 1.1-1.7)] and obese [1.1 (95% CI: 1.0-1.3), 1.6 (95% CI: 1.3-1.9)] BMI category compared with the 'healthy' weight (20-24.9 kg/m(2)) and a small WC (
KW - Waist circumference
KW - body mass index
KW - elderly
KW - mortality
U2 - 10.1093/ije/dys008
DO - 10.1093/ije/dys008
M3 - Article
C2 - 22467292
SN - 0300-5771
VL - 41
SP - 805
EP - 817
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 3
ER -