The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study

M. K. Shea; S. B. Kritchevsky; F. -C. Hsu; M. Nevitt; S. L. Booth; C. K. Kwoh; T. E. McAlindon; C. Vermeer; N. Drummen; T. B. Harris; C. Womack; R. F. Loeser

doi:10.1016/j.joca.2014.12.008

The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study

M. K. Shea^*
, S. B. Kritchevsky
, F. -C. Hsu
, M. Nevitt
, S. L. Booth
, C. K. Kwoh
, T. E. McAlindon
, C. Vermeer
, N. Drummen
, T. B. Harris
, C. Womack
, R. F. Loeser

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ? SD age = 74 ? 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.Longitudinally, participants with very low plasma PK (

Original language	English
Pages (from-to)	370-378
Number of pages	9
Journal	Osteoarthritis and Cartilage
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.joca.2014.12.008
Publication status	Published - Mar 2015

Keywords

Osteoarthritis
Nutrition
Phylloquinone
Vitamin K
Matrix gla protein
Epidemiology

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Shea, M. K., Kritchevsky, S. B., Hsu, F. .-C., Nevitt, M., Booth, S. L., Kwoh, C. K., McAlindon, T. E., Vermeer, C., Drummen, N., Harris, T. B., Womack, C., & Loeser, R. F. (2015). The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study. Osteoarthritis and Cartilage, 23(3), 370-378. https://doi.org/10.1016/j.joca.2014.12.008

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title = "The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study",

abstract = "Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ? SD age = 74 ? 3 y; 67\% female). The adjusted odds ratios (and 95\% confidence intervals) [OR (95\%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.Longitudinally, participants with very low plasma PK (",

keywords = "Osteoarthritis, Nutrition, Phylloquinone, Vitamin K, Matrix gla protein, Epidemiology",

author = "Shea, \{M. K.\} and Kritchevsky, \{S. B.\} and Hsu, \{F. -C.\} and M. Nevitt and Booth, \{S. L.\} and Kwoh, \{C. K.\} and McAlindon, \{T. E.\} and C. Vermeer and N. Drummen and Harris, \{T. B.\} and C. Womack and Loeser, \{R. F.\}",

year = "2015",

month = mar,

doi = "10.1016/j.joca.2014.12.008",

language = "English",

volume = "23",

pages = "370--378",

journal = "Osteoarthritis and Cartilage",

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Shea, MK, Kritchevsky, SB, Hsu, F-C, Nevitt, M, Booth, SL, Kwoh, CK, McAlindon, TE, Vermeer, C, Drummen, N, Harris, TB, Womack, C & Loeser, RF 2015, 'The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study', Osteoarthritis and Cartilage, vol. 23, no. 3, pp. 370-378. https://doi.org/10.1016/j.joca.2014.12.008

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T1 - The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study

AU - Shea, M. K.

AU - Kritchevsky, S. B.

AU - Hsu, F. -C.

AU - Nevitt, M.

AU - Booth, S. L.

AU - Kwoh, C. K.

AU - McAlindon, T. E.

AU - Vermeer, C.

AU - Drummen, N.

AU - Harris, T. B.

AU - Womack, C.

AU - Loeser, R. F.

PY - 2015/3

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N2 - Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ? SD age = 74 ? 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.Longitudinally, participants with very low plasma PK (

AB - Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ? SD age = 74 ? 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.Longitudinally, participants with very low plasma PK (

KW - Osteoarthritis

KW - Nutrition

KW - Phylloquinone

KW - Vitamin K

KW - Matrix gla protein

KW - Epidemiology

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DO - 10.1016/j.joca.2014.12.008

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C2 - 25528106

SN - 1063-4584

VL - 23

SP - 370

EP - 378

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 3

ER -

The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study

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Keywords

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