The association between three major physiological stress systems and oxidative DNA and lipid damage

Catherine N. Black, Mariska Bot, Dora Revesz, Peter G. Scheffer, Brenda Penninx*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Web of Science)

Abstract

Background: Increased activity of the three major physiological stress systems (immune-inflammatory system, hypothalamic-pituitary-adrenal-axis [HPA-axis], and autonomic nervous system [ANS]) is part of the pathophysiology of various somatic and psychiatric"diseases. Oxidative damage is a key mechanism in both ageing and disease. Elucidating the relationship between these stress systems and oxidative damage would contribute to the understanding of the role of physiological stress in disease. This study therefore investigates associations between various measures of physiological stress and oxidative DNA (8-hydroxy-2'-deoxyguanosine, 8-OHdG) and lipid (F2-isoprostanes) damage.

Methods: Plasma 8-OHdG and F2-isoprostanes were measured using LC-MS/MS in 2858 subjects (aged 18-65). Plasma inflammation markers, salivary cortisol and ANS markers (three for each stress system) were determined. Linear regression analyses were adjusted for sociodemographics, sampling factors and medication.

Results: 8-OHdG was positively associated with all inflammation markers (beta=0.047-0.050, p <0.01), evening cortisol (( = 0.073, p1 marker in the high risk quartile showed a positive linear trend with both 8-OHdG (p= 0.030) and F2-isoprostanes (p =0.009).

Conclusion: This large-scale study showed that markers of inflammation, the HPA-axis and ANS are associated with oxidative DNA damage. Oxidative lipid damage is associated with inflammation and the ANS. Increased physiological stress across systems is associated with increasing oxidative damage in a dose-response fashion. 2017 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)56-66
Number of pages11
JournalPsychoneuroendocrinology
Volume80
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Oxidative damage
  • 8-Hydroxy-2 '-deoxyguanosine (8-OHdG)
  • F2-isoprostanes
  • Inflammation
  • Hypothalamic-pituitary-adrenal axis
  • Autonomic nervous system
  • CARDIOVASCULAR RISK-FACTORS
  • METABOLIC SYNDROME
  • SALIVARY CORTISOL
  • ESSENTIAL-HYPERTENSION
  • FREE-RADICALS
  • DISEASE
  • F-2-ISOPROSTANES
  • PROTEIN
  • INFLAMMATION
  • ANTIOXIDANTS

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