Abstract
Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age- and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, and logistic regression. FBS, insulin, HOMA-IR, GLP-1, GLP-2, and leptin were significantly higher in the obese group; ghrelin and CCK were significantly higher in lean participants, and no difference was seen for PYY. Controlling for BMI, GLP-1 was positively correlated with WtHR, while ghrelin was inversely correlated with WtHR. GLP-1 was correlated with HOMA-IR. GLP-1 was associated with obesity and IR markers in the regression model. Our results show that obese and lean adults display significant differences in plasma peptide hormone levels. GLP-1 levels were independently associated with markers of obesity and IR. Restoring the appetite hormone balance in obesity may represent a potential therapeutic target.
Original language | English |
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Article number | 1271 |
Number of pages | 12 |
Journal | Nutrients |
Volume | 14 |
Issue number | 6 |
DOIs | |
Publication status | Published - 17 Mar 2022 |
Keywords
- Adult
- Body Mass Index
- Glucagon-Like Peptide 1
- Humans
- Insulin Resistance
- Obesity
- United Arab Emirates
- glucagon-like peptide-2
- insulin
- INTESTINAL MICROBIOTA
- GHRELIN
- glucagon-like peptide-1
- cholecystokinin
- CARDIOMETABOLIC RISK-FACTORS
- PLASMA
- TO-HEIGHT RATIO
- brain-gut axis
- peptide yy
- insulin resistance
- obesity
- ADIPOSE-TISSUE
- METABOLIC SYNDROME
- CCK
- leptin
- ghrelin
- WAIST CIRCUMFERENCE
- BODY-MASS INDEX