@article{052bbae9a7e14575b581e71fd2c55265,
title = "The association between genome-wide polymorphisms and chronic postoperative pain: a prospective observational study",
abstract = "Chronic postoperative pain is common and can have a negative impact on quality of life. Recent studies show that genetic risk factors are likely to play a role, although only gene-targeted analysis has been used to date. This is the first genome-wide association study to identify single-nucleotide polymorphisms associated with the development of chronic postoperative pain based on two independent cohorts. In a discovery cohort, 330 women scheduled for hysterectomy were genotyped. A case-control association analysis compared patients without chronic postoperative pain and the 34 who had severe chronic postoperative pain 3 months after surgery. No single-nucleotide polymorphisms reached genome-wide significance, but several showed suggestive associations with chronic postoperative pain (p <1 x 10(-5)). Single-nucleotide polymorphisms with significance p NAV3 was significantly replicated with chronic postoperative pain in the replication cohort (p = 0.009). Meta-analysis revealed that two loci (IQGAP1 and CRTC3) were significantly associated with chronic postoperative pain at 3 months (IQGAP1 p = 3.93 x 10(-6) beta = 2.3863, CRTC3 p = 2.26 x 10(-6), beta = 2.4209). The present genome-wide association study provides initial evidence for genetic risk factors of chronic postoperative pain and supports follow-up studies.",
keywords = "chronic pain, genome-wide association study, risk factors, CHRONIC POSTSURGICAL PAIN, NERVOUS-SYSTEM, RISK-FACTORS, PREVALENCE, EXPRESSION, IMPUTATION, DISEASES, SURGERY, GENES, LOCI",
author = "{van Reij}, {R. R.} and Hoofwijk, {D. M. N.} and Rutten, {B. P. F.} and L. Weinhold and M. Leber and Joosten, {E. A. J.} and A. Ramirez and {van den Hoogen}, {N. J.} and M. Allegri and E. Bassoricci and S. Bettinelli and D. Bugada and Cedrati, {V. L. E.} and G. Cappelleri and C. Compagnone and {De Gregori}, M. and R. Fumagalli and S. Grimaldi and M. Mantelli and M. Molinaro and M. Zorzetto and {Italian Pain Group}",
note = "Funding Information: We thank all the participants in this study for their contribution. The discovery cohort was registered at the Dutch trial registry under the number NTR2702 ( http://www.trialregister.nl/trialreg/index.asp ). The replication cohort was registered at the Clinical Trials registry under the numbers NCT02002663 and NCT01989351 ( https://clinicaltrials.gov/ct2/home).This work was supported by funds made available by Department of Anaesthesiology (Maastricht University Medical Center + (MUMC + ), and School of Mental Health, and Neuroscience (MHeNS, University of Maastricht) and the Italian Health Ministry ({\textquoteleft}New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids{\textquoteright}). No competing interests declared. NvdH is now employed at Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. 1 Publisher Copyright: {\textcopyright}2020 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetist",
year = "2020",
month = jan,
doi = "10.1111/anae.14832",
language = "English",
volume = "75",
pages = "E111--E120",
journal = "Anaesthesia",
issn = "0003-2409",
publisher = "Wiley",
number = "S1",
}